Establishment and identification of a human megakaryocytic cell line with low Ley expression
Zhongguo shuxue zazhi, 2022 Objective To establish a stable human megakaryocytic cell line with low expression of Ley antigen to further study the role of Ley on activation of platelets.
Huijun ZHU +4 more
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Fucosyltransferases: structure/function studies [PDF]
Glycobiology, 2001 Alpha3-fucosyltransferases (alpha3-FucTs) catalyze the final step in the synthesis of a range of important glycoconjugates that function in cell adhesion and lymphocyte recirculation. Six members of this family of enzymes have been cloned from the human genome, and their expression pattern has been shown to be highly regulated. Each enzyme has a unique
T, de Vries +3 more
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Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment [PDF]
Cytotherapy, 2014 Background aims: Advantages associated with the use of cord blood (CB) transplantation include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-versus-host disease compared with bone marrow or mobilized peripheral blood. However, poor engraftment remains a major obstacle.
Simon N, Robinson +20 more
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Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology
Frontiers in Genetics, 2020 Otitis media (OM) is an infective and inflammatory disorder known to be a major cause of hearing impairment across all age groups. Both acute and chronic OM result in substantial healthcare utilization related to antibiotic prescription and surgical ...
Arnaud P. J. Giese +5 more
doaj +1 more source
Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis. [PDF]
PLoS ONE, 2017 The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-
Rieko Ajima, Emiko Suzuki, Yumiko Saga
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Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells. [PDF]
, 2019 FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer ...
Chang, Nai-Chuan +9 more
core +2 more sources
Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY
Nature Communications, 2023 Kumar and colleagues report cryo-EM structures of Arabidopsis O-fucosyltransferase SPINDLY in its apo and GDP-fucose bound states, revealing distinct active-site features enabling GDP-fucose recognition and surprisingly dynamic conformations that ...
Shivesh Kumar +14 more
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Allele frequency of A385T in Fucosyltransferase 2 gene (FUT2) among Southern Thai population [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2020 Fucosyltransferase 2 gene (FUT2) gene plays an important role in control of enzymes that secrete blood type antigen substances. The mutation of FUT2 at nucleotide position 385 from A to T (A385T) combined with secretor phenotype is associated with ...
Darinnat Buathong +2 more
doaj +1 more source
The possibility of positive selection for both F18(+) Escherichia coli and stress resistant pigs opens new perspectives for pig breeding [PDF]
, 2007 International ...
Coddens, Annelies +7 more
core +3 more sources
The Clinical Utility of Biochemical Biomarkers in Colorectal Cancer [PDF]
Middle East Journal of CancerColorectal cancer (CRC) ranks as the third most prevalent cancer worldwide and is a leading cause of cancer-related mortality. Since many colon cancers present no significant clinical symptoms, identifying new biomarkers or a set of biological indicators
Durdi Qujeq +5 more
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