Contributions of chaperone and glycosyltransferase activities of -fucosyltransferase 1 to Notch signaling [PDF]
, 2008 Background O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe.
Irvine Kenneth D +3 more
core +2 more sources
Subcellular localisation of cerebral fucosyltransferase [PDF]
FEBS Letters, 1984 GDP‐fucose : asialofetuin fucosyltransferase from sheep brain was fractionated on a sucrose gradient into two activity peaks. Using purification on Ficoll adapted from the proposed method [(1980) J. Neurochem. 35, 281‐296], double localisation of cerebral fucosyltransferase was confirmed and the subcellular active fractions identified as light ...
Broquet, P. +4 more
openaire +3 more sources
The Function of Fucosylation in Progression of Lung Cancer
Frontiers in Oncology, 2018 Lung cancer is a disease that influences human health and has become a leading cause of cancer mortality worldwide. However, it is frequently diagnosed at the advanced stage.
Liyuan Jia +9 more
doaj +1 more source
Fucosyltransferase 2: A Genetic Risk Factor for Intestinal Diseases
Frontiers in Microbiology, 2022 The fucosyltransferase 2 gene (FUT2) mediates the synthesis of histoblood group antigens (HBGA) that occur in vivo from multiple organs, particularly on the surface of intestinal epithelial cells and body fluids.
Mingyang Hu +5 more
doaj +1 more source
Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding [PDF]
, 2007 Fertilization depends on successful binding of the spermatozoa to the zona pellucida of the oocyte. Glycodelin-A inhibits spermatozoa-zona pellucida binding.
Chiu, PCN +8 more
core +1 more source
Recent Progress on Fucosyltransferase Inhibitors
Mini-Reviews in Medicinal Chemistry, 2012 Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the ...
Merino, Pedro +5 more
openaire +3 more sources
Stage‐specific expression of α1,2‐fucosyltransferase and α1,3‐fucosyltransferase (FT) during mouse embryogenesis [PDF]
European Journal of Biochemistry, 1999 Lex[Galβ1–4(Fucα1–3)GlcNAc] and Ley[Fucα1–2Galβ1–4(Fucα1–3)GlcNAc] are both stage‐specific embryonic antigens. Lex is first detected on the blastomeres of the 8‐cell stage embryo, which correlates with the onset of blastomere compaction. Ley is highly expressed on the surface of the blastocyst, which has been shown to be involved in blastocyst ...
N, Liu +7 more
openaire +3 more sources
Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation [PDF]
, 2018 FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases.
Bearden, David R. +9 more
core +1 more source
Fucosyltransferases in Schistosoma mansoni development [PDF]
Glycobiology, 2001 Glycoconjugate-bound fucose, abundant in the parasite Schistosoma mansoni, has been found in the form of Fucalpha1,3GlcNAc, Fucalpha1,2Fuc, Fucalpha1,6GlcNAc, and perhaps Fucalpha1,4GlcNAc linkages. Here we quantify fucosyltransferase activities in three developmental stages of S. mansoni.
E T, Marques +5 more
openaire +2 more sources
The contribution of fucosyltransferases to cancer biology [PDF]
Brazilian Journal of BiologyFucosyltransferases are enzymes that transfer L-fucose residues from a donor substrate to target molecules. These enzymes are encoded by genes known as FUTs (FUT1 to FUT-11), along with POFUT1 and 2.
A. O. Vasconcelos +3 more
doaj +1 more source