Results 41 to 50 of about 15,330 (252)

The Function of Fucosylation in Progression of Lung Cancer

Frontiers in Oncology, 2018
Lung cancer is a disease that influences human health and has become a leading cause of cancer mortality worldwide. However, it is frequently diagnosed at the advanced stage.
Liyuan Jia, Jing Zhang, Tianran Ma, Yayuan Guo, Yuan Yu, Yuan Yu, Yuan Yu, Jihong Cui, Jihong Cui, Jihong Cui   +9 more
doaj   +1 more source

Recent Progress on Fucosyltransferase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2012
Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the ...
Merino, Pedro, Tejero, Tomás, Delso, J. Ignacio, Hurtado-Guerrero, Ramón, Gómez-SanJuan, Asier, Sádaba, David   +5 more
openaire   +3 more sources

Stage‐specific expression of α1,2‐fucosyltransferase and α1,3‐fucosyltransferase (FT) during mouse embryogenesis [PDF]

European Journal of Biochemistry, 1999
Lex[Galβ1–4(Fucα1–3)GlcNAc] and Ley[Fucα1–2Galβ1–4(Fucα1–3)GlcNAc] are both stage‐specific embryonic antigens. Lex is first detected on the blastomeres of the 8‐cell stage embryo, which correlates with the onset of blastomere compaction. Ley is highly expressed on the surface of the blastocyst, which has been shown to be involved in blastocyst ...
N, Liu, C, Jin, Z M, Zhu, J, Zhang, H, Tao, C, Ge, S, Yang, S, Zhang   +7 more
openaire   +3 more sources

Fucosyltransferases in Schistosoma mansoni development [PDF]

Glycobiology, 2001
Glycoconjugate-bound fucose, abundant in the parasite Schistosoma mansoni, has been found in the form of Fucalpha1,3GlcNAc, Fucalpha1,2Fuc, Fucalpha1,6GlcNAc, and perhaps Fucalpha1,4GlcNAc linkages. Here we quantify fucosyltransferase activities in three developmental stages of S. mansoni.
E T, Marques, Y, Ichikawa, M, Strand, J T, August, G W, Hart, R L, Schnaar   +5 more
openaire   +2 more sources

The contribution of fucosyltransferases to cancer biology [PDF]

Brazilian Journal of Biology
Fucosyltransferases are enzymes that transfer L-fucose residues from a donor substrate to target molecules. These enzymes are encoded by genes known as FUTs (FUT1 to FUT-11), along with POFUT1 and 2.
A. O. Vasconcelos, L. M. Vieira, C. R. C. Rocha, E. I. C. Beltrão   +3 more
doaj   +1 more source

A new superfamily of protein-O-fucosyltransferases,  2-fucosyltransferases, and  6-fucosyltransferases: phylogeny and identification of conserved peptide motifs [PDF]

Glycobiology, 2003
The presence of three conserved peptide motifs shared by alpha2-fucosyltransferases, alpha6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by ...
Ivan, Martinez-Duncker, Rosella, Mollicone, Jean-Jacques, Candelier, Christelle, Breton, Rafael, Oriol   +4 more
openaire   +2 more sources

Inactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans

Frontiers in Plant Science, 2017
Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with plant-typical residues [β(1,2)-xylose and core α(1,3)-fucose], which can greatly impact the ...
S. Mercx, Nicolas Smargiasso, F. Chaumont, E. De Pauw, M. Boutry, C. Navarre   +5 more
semanticscholar   +1 more source

Fucosyltransferase 2 inhibitors: Identification via docking and STD-NMR studies.

PLoS ONE, 2021
Fucosyltransferase 2 (FUT2) catalyzes the biosynthesis of A, B, and H antigens and other important glycans, such as (Sialyl Lewisx) sLex, and (Sialyl Lewisy) sLey.
Humaira Zafar, Muhammad Atif, Atia-Tul-Wahab, M Iqbal Choudhary   +3 more
doaj   +1 more source

Human α1,3/4 Fucosyltransferases [PDF]

Journal of Biological Chemistry, 2000
residues, in addition to a free Cys residue that lies near the binding site for GDP-fucose (Holmes, E. H.,
Eric H. Holmes, Ten‐Yang Yen, Scott Thomas, Rajesh K. Joshi, Anton Nguyen, T. Long, F. Gallet, Abderrahman Maftah, Raymond Julien, Bruce A. Macher   +9 more
openaire   +3 more sources

Multi‐level metabolic engineering of Escherichia coli for high‐titer biosynthesis of 2′‐fucosyllactose and 3‐fucosyllactose

Microbial Biotechnology, 2022
Fucosyllactoses (FL), including 2′‐fucosyllactose (2′‐FL) and 3‐fucosyllactose (3‐FL), have garnered considerable interest for their value in newborn formula and pharmaceuticals.
Mengli Li, Chenchen Li, Yejiao Luo, Miaomiao Hu, Zhu Liu, Tao Zhang   +5 more
doaj   +1 more source