Results 41 to 50 of about 19,439 (257)

α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish

Cells, 2022
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycans. Fut8 is widely conserved from Caenorhabditis elegans to humans, and its mutants have been reported in humans ...
Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa   +7 more
openaire   +3 more sources

A Surface Plasmon Resonance‐Based Integrated Assay for Quantification and Glycosylation Characterization of Monoclonal Antibodies in Crude Heterogeneous Samples

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer, Catherine Forest‐Nault, Julie Guimond, Simon Joubert, Olivier Henry, Yves Durocher, Gregory De Crescenzo, Jimmy Gaudreault   +7 more
wiley   +1 more source

Will xenotransplantation ever be feasible? [PDF]

, 1998
In several recent conferences, the principal questions have been whether xenotransplantation technology should be encouraged and, if so, how it should be regulated.
Demetris, AJ, Fung, J, Murase, N, Rao, AS, Starzl, TE   +4 more
core   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Characterization of Fut10 and Fut11, Putative Alpha-1-3/4 Fucosyltransferase Genes Important for Vertebrate Development [PDF]

, 2007
Two new, putative alpha-1-3/4 fucosyltransferases ([alpha]1-3/4 Fuc-Ts), Fuc-TX and Fuc-TXI, were identified in the vertebrate genome and transcriptome sequence databases through sequence homology-based queries. These proteins have a significant sequence
Santosh K. Patnaik
core   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Cell adhesion mediated by a purified fucosyltransferase. [PDF]

Proceedings of the National Academy of Sciences, 1983
Human embryonic skin fibroblasts attach and spread on surfaces on which a fucosyltransferase purified from human milk has been immobilized. The adhesion-enhancing effect of the transferase involves specific interactions of the enzyme surface with the cell surface carbohydrate acceptors, as suggested by the following findings.
Heikki Rauvala, Jukka Finne, Jean-Paul Prieels   +2 more
openaire   +3 more sources

Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons [PDF]

, 2014
The instant blood-mediated inflammatory reaction (IBMIR) is a major obstacle to the engraftment of intraportal pig islet xenografts in primates. Higher expression of the galactose-α1,3-galactose (αGal) xenoantigen on neonatal islet cell clusters (NICC ...
Barlow, H, Burns, H, Cowan, P J, D'Apice, A J F, Hawkes, J, Hawthorne, W J, Hu, M, Lew, A M, Liuwantara, D, Nottle, M B, O'Connell, P J, Peirce, S B, Phillips, P, Robson, S C, Salvaris, E J, Stewart, A B   +15 more
core   +4 more sources

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. [PDF]

, 2016
Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers.
Cho, Huan-Chieh, Ho, Ming-Yi, Hung, Jung-Tung, Tan, Keng-Poo, Yu, Alice Lin-Tsing, Yu, John   +5 more
core