Results 41 to 50 of about 17,134 (208)

A new superfamily of protein-O-fucosyltransferases,  2-fucosyltransferases, and  6-fucosyltransferases: phylogeny and identification of conserved peptide motifs [PDF]

Glycobiology, 2003
The presence of three conserved peptide motifs shared by alpha2-fucosyltransferases, alpha6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by ...
Ivan, Martinez-Duncker, Rosella, Mollicone, Jean-Jacques, Candelier, Christelle, Breton, Rafael, Oriol   +4 more
openaire   +2 more sources

Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb [PDF]

, 2009
Fucose-α(1−2)-galactose [Fucα(1−2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of information regarding
Domino, Steven E., Ficarro, Scott B., Hsieh-Wilson, Linda C., Krishnamurthy, Chithra, Murrey, Heather E., Peters, Eric C.   +5 more
core   +4 more sources

Fucosyltransferase 2 inhibitors: Identification via docking and STD-NMR studies.

PLoS ONE, 2021
Fucosyltransferase 2 (FUT2) catalyzes the biosynthesis of A, B, and H antigens and other important glycans, such as (Sialyl Lewisx) sLex, and (Sialyl Lewisy) sLey.
Humaira Zafar, Muhammad Atif, Atia-Tul-Wahab, M Iqbal Choudhary   +3 more
doaj   +1 more source

Human α1,3/4 Fucosyltransferases [PDF]

Journal of Biological Chemistry, 2000
residues, in addition to a free Cys residue that lies near the binding site for GDP-fucose (Holmes, E. H.,
Eric H. Holmes, Ten‐Yang Yen, Scott Thomas, Rajesh K. Joshi, Anton Nguyen, T. Long, F. Gallet, Abderrahman Maftah, Raymond Julien, Bruce A. Macher   +9 more
openaire   +3 more sources

Multi‐level metabolic engineering of Escherichia coli for high‐titer biosynthesis of 2′‐fucosyllactose and 3‐fucosyllactose

Microbial Biotechnology, 2022
Fucosyllactoses (FL), including 2′‐fucosyllactose (2′‐FL) and 3‐fucosyllactose (3‐FL), have garnered considerable interest for their value in newborn formula and pharmaceuticals.
Mengli Li, Chenchen Li, Yejiao Luo, Miaomiao Hu, Zhu Liu, Tao Zhang   +5 more
doaj   +1 more source

Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

PLoS Genetics, 2010
Over half of all proteins are glycosylated, and alterations in glycosylation have been observed in numerous physiological and pathological processes.
Gordan Lauc, Abdelkader Essafi, Jennifer E Huffman, Caroline Hayward, Ana Knežević, Jayesh J Kattla, Ozren Polašek, Olga Gornik, Veronique Vitart, Jodie L Abrahams, Maja Pučić, Mislav Novokmet, Irma Redžić, Susan Campbell, Sarah H Wild, Fran Borovečki, Wei Wang, Ivana Kolčić, Lina Zgaga, Ulf Gyllensten, James F Wilson, Alan F Wright, Nicholas D Hastie, Harry Campbell, Pauline M Rudd, Igor Rudan   +25 more
doaj   +1 more source

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

Nature Communications, 2020
Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García, Laura Ceballos-Laita, Sonia Serna, Raik Artschwager, Niels C. Reichardt, Francisco Corzana, Ramon Hurtado-Guerrero   +6 more
doaj   +1 more source

Fucosyltransferase 1 Mediates Angiogenesis in Rheumatoid Arthritis [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108009/1/art38648 ...
Amin, Apweiler, Carlyon, Carmeliet, Domino, Domino, Ferens-Sieczkowska, Folkman, Fukushima, Hachicha, Hakomori, Halloran, Hart, Isozaki, Isozaki, Iwamori, Kannagi, Kelly, Koch, Koch, Koch, Larsen, Macartney, Marelli-Berg, Marotte, Marotte, Mathieu, Miyoshi, Moelants, Moremen, Mori, Nakagawa, Palumberi, Park, Proost, Przybysz, Rabquer, Ritchlin, Ruth, Salcedo, Tsou, Volin, Volin, Weinblatt, Yoshida, Zhu   +45 more
core   +1 more source

Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants

mSphere
Cellular adaptations to change often involve post-translational modifications of nuclear and cytoplasmic proteins. An example found in protists and plants is the modification of serine and threonine residues of dozens to hundreds of nucleocytoplasmic ...
Megna Tiwari, Elisabet Gas-Pascual, Manish Goyal, Marla Popov, Kenjiroo Matsumoto, Marianne Grafe, Ralph Gräf, Robert S. Haltiwanger, Neil Olszewski, Ron Orlando, John C. Samuelson, Christopher M. West   +11 more
doaj   +1 more source

α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish

Cells, 2022
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycans.
Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa   +7 more
doaj   +1 more source