Results 51 to 60 of about 15,330 (252)

Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

PLoS Genetics, 2010
Over half of all proteins are glycosylated, and alterations in glycosylation have been observed in numerous physiological and pathological processes.
Gordan Lauc, Abdelkader Essafi, Jennifer E Huffman, Caroline Hayward, Ana Knežević, Jayesh J Kattla, Ozren Polašek, Olga Gornik, Veronique Vitart, Jodie L Abrahams, Maja Pučić, Mislav Novokmet, Irma Redžić, Susan Campbell, Sarah H Wild, Fran Borovečki, Wei Wang, Ivana Kolčić, Lina Zgaga, Ulf Gyllensten, James F Wilson, Alan F Wright, Nicholas D Hastie, Harry Campbell, Pauline M Rudd, Igor Rudan   +25 more
doaj   +1 more source

α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish

Cells, 2022
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycans.
Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa   +7 more
doaj   +1 more source

Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method

Science Advances, 2019
We report an efficient tool for engineering enzymes to economically produce fucosylated drugs and prebiotic supplements. Fucosylated glycoconjugates are involved in a variety of physiological and pathological processes.
Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, S. Withers, Yan Feng, Guangyu Yang   +8 more
semanticscholar   +1 more source

Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants

mSphere
Cellular adaptations to change often involve post-translational modifications of nuclear and cytoplasmic proteins. An example found in protists and plants is the modification of serine and threonine residues of dozens to hundreds of nucleocytoplasmic ...
Megna Tiwari, Elisabet Gas-Pascual, Manish Goyal, Marla Popov, Kenjiroo Matsumoto, Marianne Grafe, Ralph Gräf, Robert S. Haltiwanger, Neil Olszewski, Ron Orlando, John C. Samuelson, Christopher M. West   +11 more
doaj   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

The alteration and role of glycoconjugates in Alzheimer’s disease

Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by abnormal protein deposition. With an alarming 30 million people affected worldwide, AD poses a significant public health concern.
Yue Kang, Qian Zhang, Silu Xu, Yue Yu
doaj   +1 more source

FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

Communications Biology, 2021
Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues.
Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke   +19 more
doaj   +1 more source

Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells

Cell Death Discovery, 2019
FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer ...
Tai-Yu Lai, I-Ju Chen, Ruey-Jen Lin, G. Liao, H. Yeo, C. Ho, Jen-Chien Wu, N. Chang, A. Lee, A. Yu   +9 more
semanticscholar   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response

PLoS ONE, 2023
GlycoMaple is a new tool to predict glycan structures based on the expression levels of 950 genes encoding glycan biosynthesis-related enzymes and proteins using RNA-seq data.
Yuki M. Kyunai, Mika Sakamoto, Mayuko Koreishi, Yoshio Tsujino, Ayano Satoh   +4 more
doaj   +2 more sources