Results 51 to 60 of about 19,439 (257)

Glycosylated notch and cancer [PDF]

, 2016
Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development.
Couto, Africa, Georgiou, Marios, Nagarajan, Usha, Pakkiriswami, Shanmugasundaram   +3 more
core   +1 more source

Maternal Dietary Fiber Intake During Lactation and Human Milk Oligosaccharide Fucosylation: a PRIMA Birth Cohort Study

Molecular Nutrition &Food Research, EarlyView.
Healthy breastfeeding women were recruited within the prospective birth cohort PRIMA. We collected a fresh human milk sample at 1 month postpartum to assess relative human milk oligosaccharide (HMO), HMO‐bound fucose levels, and secretor status. In univariate and multivariate linear regression analysis, we did not observe an association between ...
Anneke H. Hellinga, Samanta Cajic, Hanneke F. Linde, Arthur H. van Stigt, Jeanne H. M. de Vries, Elske M. Brouwer‐Brolsma, René Hennig, Erdmann Rapp, Marko Mank, Bernd Stahl, Aletta D. Kraneveld, Jeanette H. W. Leusen, Louis Bont, Belinda van't Land, the PRIMA group   +14 more
wiley   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Trafficking and localization studies of recombinant α1,3-fucosyltransferase VI stably expressed in CHO cells [PDF]

, 2017
Peripheral α1,3-fucosylation of glycans occurs by the action of either one of five different α1,3-fucosyltransferases (Fuc-Ts) cloned to date. Fuc-TVI is one of the α1,3-fucosyltransferases which is capable to synthesize selectin ligands.
Berger, Eric G., Borsig, Lubor, Bowen, Benjamin R., Katopodis, Andreas G.   +3 more
core  

Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb [PDF]

, 2009
Fucose-α(1−2)-galactose [Fucα(1−2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of information regarding
Domino, Steven E., Ficarro, Scott B., Hsieh-Wilson, Linda C., Krishnamurthy, Chithra, Murrey, Heather E., Peters, Eric C.   +5 more
core   +4 more sources

A fucosyltransferase inhibition assay using image-analysis and digital microfluidics.

Biomicrofluidics, 2019
Sialyl-LewisX and LewisX are cell-surface glycans that influence cell-cell adhesion behaviors. These glycans are assembled by α(1,3)-fucosyltransferase enzymes.
L. Leclerc, Guy Soffer, D. Kwan, Steve C. C. Shih   +3 more
semanticscholar   +1 more source

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, EarlyView.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

Human α1,3/4-Fucosyltransferases [PDF]

Journal of Biological Chemistry, 1998
An analysis of the acceptor substrate specificity of domain swap mutants of human alpha1,3/4-fucosyltransferases (FucTs) III and V has been carried out. The results demonstrate that changing Asp336 of FucT III to Ala (as in FucT V) produced a protein (III/V1) with a reduced activity with a variety of acceptors.
Loc Vo, Stephanie Lee, Eric H. Holmes, Marie C. Marcinko, Bruce A. Macher   +4 more
openaire   +2 more sources

Overexpression of α (1,6) fucosyltransferase in the development of castration-resistant prostate cancer cells

Prostate Cancer and Prostatic Diseases, 2018
Glycosylation is recognized as one of the most common modifications on proteins. Recent studies have shown that aberrant expression of α (1,6) fucosyltransferase (FUT8), which catalyzes the transfer of fucose from GDP-fucose to core-GlcNAc of the N ...
N. Höti, Shuang Yang, Yingwei Hu, Punit Shah, Michael C. Haffner, Hui Zhang   +5 more
semanticscholar   +1 more source

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source