Results 81 to 90 of about 15,330 (252)

Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM

Journal of Translational Medicine, 2023
Background Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate the effect and underlying mechanism
Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou, Rong Lin   +8 more
doaj   +1 more source

Protein O-Fucosyltransferase 1 Undergoes Interdomain Flexibility in Solution

Molecules, 2021
Protein O-fucosyltransferase 1 (PoFUT1) is a GT-B fold enzyme that fucosylates proteins containing EGF-like repeats. GT-B glycosyltransferases have shown a remarkable grade of plasticity adopting closed and open conformations as a way of tuning their ...
Erandi Lira-Navarrete, María Carmen Pallarés, Fabio Castello, Maria J. Ruedas-Rama, Angel Orte, Anabel Lostao, Ramón Hurtado-Guerrero   +6 more
doaj   +1 more source

Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants

Microbiome, 2015
BackgroundIndividuals with inactive alleles of the fucosyltransferase 2 gene (FUT2; termed the ‘secretor’ gene) are common in many populations. Some members of the genus Bifidobacterium, common infant gut commensals, are known to consume 2′-fucosylated ...
Zachery T Lewis, Sarah M. Totten, J. Smilowitz, Mina Popovic, Evan A. Parker, D. Lemay, M. L. Van Tassell, Michael J. Miller, Yong‐Su Jin, J. B. German, C. Lebrilla, David A. Mills   +11 more
semanticscholar   +1 more source

Genome‐wide association and haplotype analyses reveal genetic architecture of seed dormancy in grain sorghum with implications for preharvest sprouting tolerance

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Preharvest sprouting (PHS), triggered primarily by wet or humid conditions at maturity and further influenced by temperature, causes premature grain germination in sorghum (Sorghum bicolor (L.) Moench), reducing yield and grain quality. To elucidate the genetic architecture of seed dormancy and germination responses related to PHS tolerance ...
Yusa Ichinose, Dinesh Kumar Saini, Juliana M. Espíndola Lima, Gunvant B. Patil, Impa Somayanda, S. V. Krishna Jagadish   +5 more
wiley   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +1 more source

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Glycobiology, 2018
Aberrant fucosylation in cancer cells is considered as a signature of malignant cell transformation and it is associated with tumor progression, metastasis and resistance to chemotherapy.
Athanasios Blanas, L. Cornelissen, Maximilianos Kotsias, Joost C. van der Horst, Henri J. van de Vrugt, H. Kalay, D. Spencer, R. P. Kozak, S. V. van Vliet   +8 more
semanticscholar   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, Volume 24, Issue 1, Page 224-238, January 2026.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

bioRxiv, 2019
Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar GDP-Fuc has been ...
Giulia Bandini, S. Damerow, M. L. Güther, Hongjie Guo, A. Mehlert, S. Beverley, M. Ferguson   +6 more
semanticscholar   +1 more source