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Fumonisin Toxicity and Sphingolipid Biosynthesis
1996Fumonisins are inhibitors of sphinganine (sphingosine) N-acyltransferase (ceramide synthase) in vitro, and exhibit competitive-type inhibition with respect to both substrates of this enzyme (sphinganine and fatty acyl-CoA). Removal of the tricarballylic acids from fumonisin B1 reduces the potency by at least 10 fold; and fumonisin A1 (which is ...
A H, Merrill +11 more
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Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Sphingoid bases are growth inhibitory and pro-apoptotic for many types of cells when added to cells exogenously, and can be elevated to toxic amounts endogenously when cells are exposed to inhibitors of ceramide synthase. An important category of naturally occurring inhibitors are the fumonisins, which inhibit ceramide synthase through structural ...
Kena, Desai +9 more
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Mycotoxin Research, 2001
It is well-known that fumonisin B1 (FB1) stimulates apoptosis in a variety of cell types and tissues but the apoptotic potential of other fumonisins and fumonisin metabolites has not been investigated. In our studies we exposed human proximal tubule-derived cells (IHKE cells) to FB1, fumonisin B2 (FB2), hydrolyzed fumonisin B1 (HFB1) and N-palmitoyl ...
W, Seefelder +4 more
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It is well-known that fumonisin B1 (FB1) stimulates apoptosis in a variety of cell types and tissues but the apoptotic potential of other fumonisins and fumonisin metabolites has not been investigated. In our studies we exposed human proximal tubule-derived cells (IHKE cells) to FB1, fumonisin B2 (FB2), hydrolyzed fumonisin B1 (HFB1) and N-palmitoyl ...
W, Seefelder +4 more
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Immunochemical Methods for Fumonisins
1996Both monoclonal and polyclonal antibodies have been raised against fumonisins (Fm) and the hydrolyzed toxin in several laboratories. They have been used in several immunoassays and can detect 5 to 5000 ng of FmB1/mL in a "clean" standard solution. However, sample matrices still give severe interferences.
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1996
Occurrence of Fumonisins in Foods and Feeds: Fumonisins: History, Worldwide Occurrence and Impact W.F.O. Marasas Occurrence of Fumonisins in the US Food Supply A.E. Pohland Occurrence of Fusarium and Fumonisins on Food Grains and in Foods L.B. Bullerman Occurrence and Fate of Fumonisins in Beef J.S. Smith, R.A.
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Occurrence of Fumonisins in Foods and Feeds: Fumonisins: History, Worldwide Occurrence and Impact W.F.O. Marasas Occurrence of Fumonisins in the US Food Supply A.E. Pohland Occurrence of Fusarium and Fumonisins on Food Grains and in Foods L.B. Bullerman Occurrence and Fate of Fumonisins in Beef J.S. Smith, R.A.
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