Results 51 to 60 of about 304,354 (194)
Nonpathological extracellular amyloid is present during normal epididymal sperm maturation. [PDF]
PLoS ONE, 2012 Amyloids are aggregated proteins characterized by a specific cross-β-sheet structure and are typically associated with neurodegenerative diseases including Alzheimer's disease.
Sandra Whelly +5 more
doaj +1 more source
Thyroid function tests in amyloid goitre [PDF]
Postgraduate Medical Journal, 1990 Summary We present two patients with amyloid goitre due to primary systemic amyloidosis which was confirmed at post-mortem. Both were clinically euthyroid but had hyperthyroxinaemia and other thyroid function tests suggestive of thyrotoxicosis.
P, Duhra, J, Cassar
openaire +2 more sources
Functional Coating from Amyloid Superwetting Films
Advanced Materials, 2022 AbstractTailoring the hydrophilicity of solid surfaces with a strong affinity to water has been extensively explored in the last 20 years, but studies have been limited to the single function of wettability. Here, the multifunctional properties of tailored surface films are extended from exhibiting superwettability to facilitating biological activities.
Tonghui Jin +5 more
openaire +3 more sources
NeuroImage: Clinical, 2018 Changes in functional connectivity of cortical networks have been observed in resting-state EEG studies in healthy aging as well as preclinical and clinical stages of AD.
Stefan Teipel +10 more
doaj +1 more source
Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent manner. [PDF]
PLoS ONE, 2010 Amyloid-β interacts with two cell surface receptors, CD36 and CD47, through which the matricellular protein thrombospondin-1 inhibits soluble guanylate cyclase activation. Here we examine whether amyloid-β shares this inhibitory activity.
Thomas W Miller +4 more
doaj +1 more source
Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. [PDF]
, 2017 Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration.
Adler-Abramovich, Lihi +10 more
core +3 more sources
Segmental Polymorphism in a Functional Amyloid [PDF]
Biophysical Journal, 2011 Although amyloid fibrils are generally considered to be causative or contributing agents in amyloid diseases, several amyloid fibrils are also believed to have biological functions. Among these are fibrils formed by Pmel17 within melanosomes, which act as a template for melanin deposition. We use solid-state NMR to show that the molecular structures of
Hu, Kan-Nian +3 more
openaire +2 more sources
Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG
Molecules, 2019 Bacterial biofilms are multicellular aggregates in which cells are embedded in an extracellular matrix of self-produced biopolymers. Being refractory to antibiotic treatment and host immune systems, biofilms are involved in most chronic infections, and ...
Regine Hengge
doaj +1 more source
mBio, 2018 Curli amyloid fibers are produced as part of the extracellular biofilm matrix and are composed primarily of the major structural subunit CsgA. The CsgE chaperone facilitates the secretion of CsgA through CsgG by forming a cap at the base of the nonameric
Roger D. Klein +13 more
doaj +1 more source
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source