Results 1 to 10 of about 179,623 (257)

Use of Antisense Oligonucleotides in Functional Genomics and Target Validation

Oligonucleotides, 2004
With the completion of sequencing of the human genome, a great deal of interest has been shifted toward functional genomics-based research for identification of novel drug targets for treatment of various diseases. The major challenge facing the pharmaceutical industry is to identify disease-causing genes and elucidate additional roles for genes of ...
Lingamanaidu V, Ravichandran, Nicholas M, Dean, Eric G, Marcusson   +2 more
openaire   +2 more sources

Modulation of RNA function by oligonucleotides recognizing RNA structure

2001
Numerous RNA structures are responsible for regulatory processes either because they constitute a signal, like the hairpins or pseudoknots involved in ribosomal frameshifting, or because they are binding sites for proteins such as the trans-activating responsive RNA element of the human immunodeficiency virus whose binding to the viral protein Tat and ...
J J, Toulmé, C, Di Primo, S, Moreau
openaire   +2 more sources

High-throughput synthesis of functionalized oligonucleotides.

Nucleic acids symposium series, 1998
Functionalization of oligonucleotides with fluorescent dyes, biotin, and other reporter and capture labels is efficient, reliable, and convenient on the ABI 3948. The entire process of sequence entry, oligonucleotide synthesis, cleavage, deprotection, purification, quantitation, and sample collection is automated.
A, Andrus, S, Cox, S, Beavers, A, Parker, J, Anuskiewicz, B, Mullah   +5 more
openaire   +1 more source

Postsynthesis Functionalization of Oligonucleotides

1994
B C, Chu, L E, Orgel
openaire   +2 more sources

Functional Analysis of Individual piRNAs in Aedes aegypti Cells and Embryos Using Antisense Oligonucleotides

Methods in Molecular Biology, 2022
Rebecca Halbach, Pascal Miesen, Miesen Pascal   +2 more
exaly  

Methods for CPP Functionalization with Oligonucleotides

2023
openaire   +1 more source

Morpholino phosphorodiamidate oligonucleotides in zebrafish: A recipe for functional genomics?

Briefings in Functional Genomics & Proteomics, 2002
Sumanas Saulius, Larson Jon D
exaly  

De NovoDesign of Functional Oligonucleotides with Acyclic Scaffolds

Chemical Record, 2014
Hiromu Kashida, Yukiko Kamiya
exaly  

Synthesis of the First Tellurium‐Derivatized Oligonucleotides for Structural and Functional Studies

Chemistry - A European Journal, 2009
Jia Sheng, Abdalla Hassan, Zhen Huang
exaly  

Functional tuning of nucleic acids by chemical modifications: Tailored oligonucleotides as drugs, devices, and diagnostics

Chemical Record, 2003
Michael Famulok, Oliver Thum
exaly