Results 101 to 110 of about 1,811,201 (303)
Modelling single cell electroporation with bipolar pulse parameters and dynamic pore radii [PDF]
, 2010 We develop a model of single spherical cell electroporation and simulate spatial and temporal aspects of the transmembrane potential and pore radii as an effect of any form of applied electric field.
Cree, Michael J. +3 more
core +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Fusion Pore Selectivity in Chromaffin Cells [PDF]
Biophysical Journal, 2017 Healthy physiological conditions depend on dynamic release of neurotransmitters and hormones by exocytosis, which is initiated by the fusion pore. Previous studies show that reduction of extracellular [NaCl] decreases the amperometric foot current, indicating no co-release of anions with transmitter.
Joannalyn Delacruz +4 more
openaire +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Regulation of Exocytotic Fusion Pores by SNARE Protein Transmembrane Domains
Frontiers in Molecular Neuroscience, 2017 Calcium-triggered exocytotic release of neurotransmitters and hormones from neurons and neuroendocrine cells underlies neuronal communication, motor activity and endocrine functions.
Zhenyong Wu +7 more
doaj +1 more source
Minimum Membrane Bending Energies of Fusion Pores [PDF]
Journal of Membrane Biology, 2009 Membranes fuse by forming highly curved intermediates, culminating in structures described as fusion pores. These hourglass-like figures that join two fusing membranes have high bending energies, which can be estimated using continuum elasticity models.
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft
Frontiers in Synaptic Neuroscience, 2010 Glutamate is released from synaptic vesicles following formation of a fusion pore, connecting the vesicle interior with the synaptic cleft. Release is proposed to result from either full fusion of the vesicle with the terminal membrane or by ‘kiss-
Jon T Brown +5 more
doaj +1 more source
Fusion Pore Conductance: Experimental Approaches and Theoretical Algorithms [PDF]
Biophysical Journal, 1998 Time-resolved admittance measurements provide the basis for studies showing that membrane fusion occurs through the formation and widening of an initially small pore, linking two previously separated aqueous compartments. Here we introduce modifications to this method that correct the cell-pipette (source) admittance for attenuation and phase shifts ...
Ratinov, Vladimir +2 more
openaire +2 more sources
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source