Results 111 to 120 of about 1,811,201 (303)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain

Frontiers in Cellular Neuroscience, 2017
Upon cell stimulation, the network of cortical actin filaments is rearranged to facilitate the neurosecretory process. This actin rearrangement includes both disruption of the preexisting actin network and de novo actin polymerization.
Arlek M. González-Jamett, María J. Guerra, María J. Olivares, Valentina Haro-Acuña, Ximena Baéz-Matus, Jacqueline Vásquez-Navarrete, Fanny Momboisse, Narcisa Martinez-Quiles, Ana M. Cárdenas   +8 more
doaj   +1 more source

Dynamics of pore formation during laser powder bed fusion additive manufacturing

Nature Communications, 2019
Laser powder bed fusion additive manufacturing is an emerging 3D printing technique for the fabrication of advanced metal components. Widespread adoption of it and similar additive technologies is hampered by poor understanding of laser-metal ...
Aiden A. Martin, N. Calta, S. Khairallah, Jenny Wang, Phillip J. Depond, A. Fong, V. Thampy, G. Guss, Andrew M. Kiss, K. Stone, Christopher J. Tassone, Johanna Nelson Weker, M. Toney, T. van Buuren, M. Matthews   +14 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sub-quantal release is not dominant during prolonged depolarization in adrenal chromaffin cells

Biophysical Reports
Exocytosis, which mediates important functions like synaptic transmission and stress responses, has been postulated to release all transmitter molecules in the vesicle in the “all-or-none” quantal hypothesis.
Lisi Wei, Xin Wang, Min Sun, Wonchul Shin, Kevin D. Gillis, Ling-Gang Wu   +5 more
doaj   +1 more source

Reovirus FAST Proteins Drive Pore Formation and Syncytiogenesis Using a Novel Helix-Loop-Helix Fusion-Inducing Lipid Packing Sensor.

PLoS Pathogens, 2015
Pore formation is the most energy-demanding step during virus-induced membrane fusion, where high curvature of the fusion pore rim increases the spacing between lipid headgroups, exposing the hydrophobic interior of the membrane to water.
Jolene Read, Eileen K Clancy, Muzaddid Sarker, Roberto de Antueno, David N Langelaan, Hiren B Parmar, Kyungsoo Shin, Jan K Rainey, Roy Duncan   +8 more
doaj   +1 more source

Architecture of a nascent viral fusion pore [PDF]

The EMBO Journal, 2010
Enveloped viruses use specialized protein machinery to fuse the viral membrane with that of the host cell during cell invasion. In influenza virus, hundreds of copies of the haemagglutinin (HA) fusion glycoprotein project from the virus surface. Despite intensive study of HA and its fusion activity, the protein's modus operandi in manipulating viral ...
openaire   +2 more sources

How Could SNARE Proteins Open a Fusion Pore? [PDF]

Physiology, 2014
The SNARE (Soluble NSF Attachment protein REceptor) complex, which in mammalian neurosecretory cells is composed of the proteins synaptobrevin 2 (also called VAMP2), syntaxin, and SNAP-25, plays a key role in vesicle fusion. In this review, we discuss the hypothesis that, in neurosecretory cells, fusion pore formation is directly accomplished by a ...
Q. Fang, M. Lindau
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion

Retrovirology, 2011
Background We recently provided evidence that HIV-1 enters HeLa-derived TZM-bl and lymphoid CEMss cells by fusing with endosomes, whereas its fusion with the plasma membrane does not proceed beyond the lipid mixing step.
de la Vega Michelle, Marin Mariana, Kondo Naoyuki, Miyauchi Kosuke, Kim Yuri, Epand Raquel F, Epand Richard M, Melikyan Gregory B   +7 more
doaj   +1 more source