A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
An Archival Study on the Fusion Researches in Japan from 1965 to 1986 An Interview with Sekiguchi Tadashi [PDF]
, 2001 We here report an archival study undertaken by the method of an interview with Sekiguchi Tadashi, Professor Emeritus at the University of Tokyo. The theme covers the circumstances of the fusion research during the period (1965-1976) when fusion project ...
KAWAKAMI, Ichiro +11 more
core
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Simulated dynamic cholesterol redistribution favors membrane fusion pore constriction. [PDF]
Biophys J, 2023 Beaven AH, Sapp K, Sodt AJ.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Nuclear diagnostics for Inertial Confinement Fusion (ICF) plasmas
, 2020 Submitted for publication in Plasma Physics and Controlled FusionThe field of nuclear diagnostics for Inertial Confinement Fusion (ICF) is broadly reviewed from its beginning in the seventies to present day.
Frenje, Johan A.
core +1 more source
Synaptophysin transmembrane domain III controls fusion pore dynamics in Ca2+-triggered exocytosis. [PDF]
Biophys J, 2023 Hsiao YT, Jackson MB.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
An Archival Study on the Nuclear Fusion Researches in Japan Later Half of 1980's. An Interview with SEKIGUCHI Tadashi, Professor Emeritus at The University of Tokyo [PDF]
, 2003 An interview record with SEKIGUCHI Tadashi, Professor Emeritus at The University of Tokyo, on the nuclear fusion researches in Japan later half of 1980’s is given. The major topics concerned are : activities of Science Council of Japan, the establishment
KAWAKAMI, Ichiro +14 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source