Results 1 to 10 of about 2,444 (109)

IFITM3 at the viral fusion-pore checkpoint: membrane energetics and entry-route-dependent outcomes [PDF]

Frontiers in Immunology
Interferon-induced transmembrane proteins (IFITMs) are small interferon-stimulated membrane proteins that can limit viral entry, but their effects depend on the virus, entry route, and experimental context. This Mini Review focuses on IFITM3 at the viral
Luyu Mao, Siqi Wang, Yang Bai, Shuchang Cheng, Kaili Gao, Yiming Chang, Lianmin Li, Yongli Guo, Mingchun Gao   +8 more
doaj   +2 more sources

Cyclosporine A rescues the influenza virus fusion with IFITM3-expressing cells by relocating the restriction factor to intraluminal vesicles of multivesicular bodies [PDF]

Journal of Virology
Interferon-induced transmembrane protein 3 (IFITM3) blocks fusion of many enveloped viruses with endosomes, likely by rigidifying the cell membrane. We and others have previously reported that cyclosporine A (CsA) treatment rescues the ability of the ...
Sergey A. Buth, Mariana Marin, You Zhang, Ori Avinoam, Gregory B. Melikyan   +4 more
doaj   +2 more sources

Specific Determinants of the Transmembrane Region of the Andes Virus Gc Glycoprotein Drive the Transition from Membrane Hemifusion to Pore Formation [PDF]

Viruses
Andes virus (ANDV), a highly pathogenic orthohantavirus, enters host cells through low pH–triggered membrane fusion mediated by the Gc glycoprotein, a class II fusion protein containing a single C-terminal transmembrane domain (TMD). While the ectodomain
Chantal L. Márquez, Fernando Villalón-Letelier, Gianina Arata-Salas, Nicole D. Tischler   +3 more
doaj   +2 more sources

SERINC5 co-expressed with HIV-1 Env or present in a target membrane destabilizes small fusion pores leading to their collapse [PDF]

mBio
Serine incorporator protein 5 (SERINC5) is a multipass membrane protein that reduces infectivity of retroviruses and other enveloped viruses through incorporating into budding virions and inhibiting their ability to fuse with target cells.
Ruben M. Markosyan, Mariana Marin, Gregory B. Melikyan   +2 more
doaj   +2 more sources

Evidence Showing that Tetraspanins Inhibit HIV-1-Induced Cell-Cell Fusion at a Post-Hemifusion Stage

Viruses, 2014
Human immunodeficiency virus type 1 (HIV-1) transmission takes place primarily through cell-cell contacts known as virological synapses. Formation of these transient adhesions between infected and uninfected cells can lead to transmission of viral ...
Markus Thalí, Menelaos Symeonides
exaly   +3 more sources

Hemifusomes and interacting proteolipid nanodroplets mediate multi-vesicular body formation [PDF]

Nature Communications
The pleiomorphic structure and dynamic behavior of cellular endomembrane systems have been extensively studied using classical electron microscopy. However, fixation and staining constraints limit the in situ visualization of transient interactions, such
Amirrasoul Tavakoli, Shiqiong Hu, Seham Ebrahim, Bechara Kachar   +3 more
doaj   +2 more sources

Hemifusomes and proteolipid nanodroplets: a critical synthesis of an emerging model for endosomal membrane remodeling [PDF]

Cell Communication and Signaling
Vesicular membrane trafficking is central to eukaryotic homeostasis, governing receptor downregulation, lysosomal degradation, and intercellular communication via exosomes.
Mohammed A. Abdel-Rasol, Wael M. El-Sayed   +1 more
doaj   +2 more sources

Engineering Phosphatidylserine Containing Asymmetric Giant Unilamellar Vesicles [PDF]

Membranes
The plasma membrane lipid distribution is asymmetric, with several anionic lipid species located in its inner leaflet. Among these, phosphatidylserine (PS) plays a crucial role in various important physiological functions.
Jake McDonough, Trevor A. Paratore, Hannah M. Ketelhohn, Bella C. DeCilio, Alonzo H. Ross, Arne Gericke   +5 more
doaj   +2 more sources

Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET [PDF]

Nature Communications
SARS-CoV-2 entry into host cells is mediated by the spike protein, which drives membrane fusion. While cryo-EM reveals stable prefusion and postfusion conformations of the spike, the transient fusion intermediate states during the fusion process remain ...
Caner Akıl, Jialu Xu, Juan Shen, Peijun Zhang   +3 more
doaj   +2 more sources

Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons [PDF]

Nature Communications
Synaptic vesicle (SV) fusion is not only tightly coordinated but also happens at a millisecond timescale. Competing models for fusion initiation and propagation suggest tight docking and hemifusion of SVs or localized lipid rearrangements leading to tip ...
Jana Kroll, Uljana Kravčenko, Mohsen Sadeghi, Christoph A. Diebolder, Lia Ivanov, Małgorzata Lubas, Thiemo Sprink, Magdalena Schacherl, Mikhail Kudryashev, Christian Rosenmund   +9 more
doaj   +2 more sources