Results 21 to 30 of about 3,016 (188)

Evidence for the Extended Phospholipid Conformation in Membrane Fusion and Hemifusion [PDF]

Biophysical Journal, 1999
Molecular-level mechanisms of fusion and hemifusion of large unilamellar dioleoyl phosphatidic acid/phosphocholine (DOPA/DOPC, 1:1 molar ratio) vesicles induced by millimolar Ca2+ and Mg2+, respectively, were investigated using fluorescence spectroscopy.
Lehtonen, Jukka Y.A., Kinnunen, Paavo K.J., Holopainen, Juha M.   +2 more
core   +4 more sources

Field Theoretic Study of Bilayer Membrane Fusion. I. Hemifusion Mechanism [PDF]

Biophysical Journal, 2004
Self-consistent field theory is used to determine structural and energetic properties of metastable intermediates and unstable transition states involved in the standard stalk mechanism of bilayer membrane fusion.
Katsov, K., Müller, M., Schick, M.
core   +5 more sources

Molecular Dynamics Simulation Analysis of Membrane Defects and Pore Propensity of Hemifusion Diaphragms [PDF]

Biophysical Journal, 2013
Membrane fusion often exhibits slow dynamics in electrophysiological experiments, involving prespike foot and fusion pore-flickering, but the structural basis of such phenomena remains unclear.
Nishizawa, Kazuhisa, Nishizawa, Manami
core   +4 more sources

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes [PDF]

Nature Communications, 2015
Ca 2+-sensor proteins control the secretion of many neuroendocrine substances. Calcium-secretion coupling may involve several mechanisms. First, Ca 2+-dependent association of their tandem C2 domains with phosphatidylserine may induce membrane curvature ...
Giniatullina, A., van Weering, J.R.T., Wuite, G.J.L., Laurens, N., van Weering, J.R.T.; id_orcid, Groffen, A.J.A., Brouwer, I., Wuite, G.J.L.; id_orcid, Weering, J.R.T. van, Bald, D., Groffen, A.J.   +10 more
core   +8 more sources

Lipid Intermediates in Membrane Fusion: Formation, Structure, and Decay of Hemifusion Diaphragm [PDF]

Biophysical Journal, 2002
Lipid bilayer fusion is thought to involve formation of a local hemifusion connection, referred to as a fusion stalk. The subsequent fusion stages leading to the opening of a fusion pore remain unknown.
Chernomordik, Leonid V., Kozlovsky, Yonathan, Kozlov, Michael M.   +2 more
core   +4 more sources

Myomerger Induces Membrane Hemifusion and Regulates Fusion Pore Expansion

Biochemistry
Membrane fusion is a crucial mechanism in a wide variety of important events in cell biology from viral infection to exocytosis. However, despite many efforts and much progress, cell–cell fusion has remained elusive to our understanding.
Marcelo Caparotta (9618597), Luis Mariano Polo (11267853), Ary Lautaro Di Bartolo (12964197), Diego Masone (2402371)   +3 more
core   +4 more sources

Crystal structures of Fsc1, a novel autophagy factor that mediates autophagosome-vacuole fusion in fission yeast. [PDF]

Acta Crystallogr D Struct Biol
Crystal structures of the autophagy protein Fsc1 reveal conserved fasciclin features and a stable dimer interface that illuminate its possible role as a scaffold in autophagosome–vacuole membrane fusion.Fsc1 is a recently identified autophagy factor in the fission yeast Schizosaccharomyces pombe that is implicated in the autophagosome–vacuole fusion ...
Azuka C, Liu J, Jin X.
europepmc   +2 more sources

Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry

mBio, 2022
The lipid composition of the host cell membrane is one of the key determinants of the entry of enveloped viruses into cells. To elucidate the detailed mechanisms behind the cell entry of rubella virus (RuV), one of the enveloped viruses, we searched for ...
Yoshio Mori, Masafumi Sakata, Shota Sakai, Toru Okamoto, Yuichiro Nakatsu, Shuhei Taguwa, Noriyuki Otsuki, Yusuke Maeda, Kentaro Hanada, Yoshiharu Matsuura, Makoto Takeda   +10 more
doaj   +1 more source

Membrane Fusion-Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics. [PDF]

Adv Healthc Mater
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Lee S, Nyamzaya K, Han J, Song Y, Lee J, Jo JH, Bang S, Lim EK, Haam S, Kim E.   +9 more
europepmc   +2 more sources

A hemifused complex is the hub in a network of pathways to membrane fusion [PDF]

Biophysical Journal, 2021
Abstract Membrane fusion is a critical step for many essential processes, from neurotransmission to fertilization. For over 40 years protein-free fusion driven by calcium or other cationic species has provided a simplified model of biological fusion, but the mechanisms remain poorly understood.
Warner, Jason, An, Dong, Stratton, Benjamin, O'Shaughnessy, Ben   +3 more
openaire   +2 more sources