IFITM proteins restrict viral membrane hemifusion. [PDF]
PLoS Pathogens, 2013 The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages of viral replication; the underlying mechanism is currently not known.
Kun Li +12 more
doaj +7 more sources
Membrane bridging and hemifusion by denaturated Munc18. [PDF]
PLoS ONE, 2011 Neuronal Munc18-1 and members of the Sec1/Munc18 (SM) protein family play a critical function(s) in intracellular membrane fusion together with SNARE proteins, but the mechanism of action of SM proteins remains highly enigmatic.
Yi Xu +4 more
doaj +5 more sources
Reevaluating Herpes Simplex Virus Hemifusion [PDF]
Journal of Virology, 2010 Membrane fusion induced by enveloped viruses proceeds through the actions of viral fusion proteins. Once activated, viral fusion proteins undergo large protein conformational changes to execute membrane fusion.
Julia O. Jackson, Richard Longnecker
core +3 more sources
Kinetically Differentiating Influenza Hemagglutinin Fusion and Hemifusion Machines [PDF]
Biophysical Journal, 2003 Membrane fusion mediated by influenza virus hemagglutinin (HA) yields different phenotypes depending on the surface density of activated HAs. A key question is whether different phenotypes arise from different fusion machines or whether different numbers
Chernomordik, Leonid V. +3 more
core +4 more sources
IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion. [PDF]
PLoS Pathogens, 2014 Interferon-induced transmembrane proteins (IFITMs) inhibit infection of diverse enveloped viruses, including the influenza A virus (IAV) which is thought to enter from late endosomes.
Tanay M Desai +5 more
doaj +3 more sources
Pulling force generated by interacting SNAREs facilitates membrane hemifusion [PDF]
Integrative Biology, 2009 In biological systems, membrane fusion is mediated by specialized proteins. Although soluble N -ethylmaleimide-sensitive factor attachment protein (SNAP) receptors (SNAREs) provide the minimal molecular machinery required to drive membrane fusion, the ...
Bhalla, Akhil +11 more
core +3 more sources
Membrane Tension Inhibits Lipid Mixing by Increasing the Hemifusion Stalk Energy. [PDF]
ACS Nano, 2023 Fusion of biological membranes is fundamental in various physiological events. The fusion process involves several intermediate stages with energy barriers that are tightly dependent on the mechanical and physical properties of the system, one of which ...
Shendrik P +4 more
europepmc +7 more sources
Short-Chain Alcohols Promote an Early Stage of Membrane Hemifusion [PDF]
Biophysical Journal, 1999 Hemifusion, the linkage of contacting lipid monolayers of two membranes before the opening of a fusion pore, is hypothesized to proceed through the formation of a stalk intermediate, a local and strongly bent connection between membranes.
Chernomordik, Leonid V. +3 more
core +4 more sources
The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition [PDF]
Biophysical Journal, 1995 To fuse, membranes must bend. The energy of each lipid monolayer with respect to bending is minimized at the spontaneous curvature of the monolayer. Two lipids known to promote opposite spontaneous curvatures, lysophosphatidylcholine and arachidonic acid,
Chanturiya, A. +3 more
core +3 more sources
Productive Hemifusion Intermediates in Fast Vesicle Fusion Driven by Neuronal SNAREs [PDF]
Biophysical Journal, 2008 An in vitro fusion assay uses fluorescence microscopy of labeled lipids to monitor single v-SNARE vesicle docking and fusion events on a planar lipid bilayer containing t-SNAREs.
Wang, Tingting +3 more
core +4 more sources