Results 41 to 50 of about 3,016 (188)
Tight docking of membranes before fusion represents a metastable state with unique properties
Nature Communications, 2021 Proteins need to overcome energy barriers to induce intermediate steps in membrane fusion. Using lipid vesicles in which progression to hemifusion is arrested, the authors show that the metastable intermediate is enhanced by divalent cations and is ...
Agata Witkowska +3 more
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Host and Viral Factors in HIV-Mediated Bystander Apoptosis
Viruses, 2017 Human immunodeficiency virus (HIV) infections lead to a progressive loss of CD4 T cells primarily via the process of apoptosis. With a limited number of infected cells and vastly disproportionate apoptosis in HIV infected patients, it is believed that ...
Himanshu Garg, Anjali Joshi
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HIV-1 Induced Bystander Apoptosis
Viruses, 2012 Apoptosis of uninfected bystander cells is a key element of HIV pathogenesis and believed to be the driving force behind the selective depletion of CD4+ T cells leading to immunodeficiency.
Anjali Joshi +2 more
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The Hemifused State on the Pathway to Membrane Fusion
Physical Review Letters, 2012 Fusion of compartments enclosed by membrane bilayers enables secretion and other vital cellular processes and is widely studied in model synthetic membrane systems. Experiments suggest the fusion pathway passes through a hemifused intermediate where only outer monolayers are fused.
Jason M, Warner, Ben, O'Shaughnessy
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IFITM Proteins Block the Creation of Hemifusion [PDF]
Biophysical Journal, 2013 Interferon-inducible transmembrane (IFITM) proteins have previously been shown to potently reduce infection caused by several highly pathogenic viruses, but the mechanisms of inhibition were not identified. There are three known functional IFITM members that are widely expressed in human tissues and cell lines.
Markosyan, Ruben +4 more
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The transmembrane domain and acidic lipid flip-flop regulates voltage-dependent fusion mediated by class II and III viral proteins. [PDF]
PLoS ONE, 2013 Voltage dependence of fusion induced by class II and class III viral fusion proteins was investigated. Class II proteins from Ross River and Sindbus virus and a mutant class III protein from Epstein Barr virus were found to induce cell-cell fusion that ...
Ruben M Markosyan, Fredric S Cohen
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Simulation and prediction of membrane fusion dynamics
Theoretical and Applied Mechanics Letters, 2022 Membrane fusion is an important process by which biological membranes perform their life activities. Simulations show that the membrane fusion process happens mainly through three pathways, where the Stalk-Pore hypothesis, in which two membranes come ...
Zhi Zheng, Shouqin Lü, Mian Long
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Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion
Retrovirology, 2011 Background We recently provided evidence that HIV-1 enters HeLa-derived TZM-bl and lymphoid CEMss cells by fusing with endosomes, whereas its fusion with the plasma membrane does not proceed beyond the lipid mixing step.
de la Vega Michelle +7 more
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Fast membrane hemifusion via dewetting between lipid bilayers [PDF]
Soft Matter, 2014 The behavior of lipid bilayers is important to understand the functionality of cells like the trafficking of ions between cells.
Nabor Vargas, J. +2 more
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Cholesterol stabilizes hemifused phospholipid bilayer vesicles
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2001 Cholesterol was found to inhibit full fusion of oppositely charged phospholipid bilayer vesicles by stabilizing the contacting membranes at the stage of the hemifused intermediate. Vesicles of opposite charge containing different amounts of cholesterol were prepared using cationic (1,2-dioleoyl-sn-glycero-3-ethylphosphocholine) and anionic ...
Garcı́a, Ricardo A. +3 more
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