Results 31 to 40 of about 3,016 (188)
The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion.
PLoS Pathogens, 2021 Arenavirus entry into host cells occurs through a low pH-dependent fusion with late endosomes that is mediated by the viral glycoprotein complex (GPC). The mechanisms of GPC-mediated membrane fusion and of virus targeting to late endosomes are not well ...
Ruben M Markosyan +4 more
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Membrane Hemifusion Is a Stable Intermediate of Exocytosis [PDF]
Developmental Cell, 2007 Membrane fusion during exocytosis requires that two initially distinct bilayers pass through a hemifused intermediate in which the proximal monolayers are shared. Passage through this intermediate is an essential step in the process of secretion, but is difficult to observe directly in vivo. Here we study membrane fusion in the sea urchin egg, in which
Wong, Julian L. +3 more
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Asymmetric Bilayers by Hemifusion: Method and Leaflet Behaviors [PDF]
Biophysical Journal, 2019 We describe a new method to prepare asymmetric giant unilamellar vesicles (aGUVs) via hemifusion. Hemifusion of giant unilamellar vesicles and a supported lipid bilayer, triggered by calcium, promotes the lipid exchange of the fused outer leaflets mediated by lipid diffusion.
Thais A, Enoki, Gerald W, Feigenson
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Evolution of the Hemifused Intermediate on the Pathway to Membrane Fusion [PDF]
Biophysical Journal, 2012 The pathway to membrane fusion in synthetic and biological systems is thought to pass through hemifusion, in which the outer leaflets are fused while the inner leaflets engage in a hemifusion diaphragm (HD). Fusion has been proposed to be completed by lysis of the expanded HD that matures from a localized stalklike initial connection.
Warner, Jason M., O’Shaughnessy, Ben
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Line-tension controlled mechanism for influenza fusion. [PDF]
PLoS ONE, 2012 Our molecular simulations reveal that wild-type influenza fusion peptides are able to stabilize a highly fusogenic pre-fusion structure, i.e. a peptide bundle formed by four or more trans-membrane arranged fusion peptides.
Herre Jelger Risselada +6 more
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Exploiting Herpes Simplex Virus Entry for Novel Therapeutics
Viruses, 2013 Herpes Simplex virus (HSV) is associated with a variety of diseases such as genital herpes and numerous ocular diseases. At the global level, high prevalence of individuals who are seropositive for HSV, combined with its inconspicuous infection, remains ...
Deepak Shukla, Satvik Hadigal
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Direct Visualization of Large and Protein-free Hemifusion Diaphragms [PDF]
Biophysical Journal, 2009 Fusion of cellular membranes is a ubiquitous biological process requiring remodeling of two phospholipid bilayers. We believe it is very likely that merging of membranes proceeds via similar sequential intermediates. Contacting membranes form a stalk between the proximal leaflets that expands radially into an hemifusion diaphragm (HD) and subsequently ...
Nikolaus, Joerg +4 more
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Sequential conformational rearrangements in flavivirus membrane fusion
eLife, 2014 The West Nile Virus (WNV) envelope protein, E, promotes membrane fusion during viral cell entry by undergoing a low-pH triggered conformational reorganization.
Luke H Chao +4 more
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Nature Communications, 2021 Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore by ...
Gonen Golani +8 more
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Role of HIV Gp41 mediated fusion/hemifusion in bystander apoptosis [PDF]
Cellular and Molecular Life Sciences, 2008 Mechanisms of HIV-mediated CD4+ T cell loss leading to immunodeficiency are amongst the most extensively studied yet unanswered questions in HIV biology. The level of CD4+ T cell depletion in HIV infected patients far exceeds the number of infected T cells, suggesting an indirect mechanism of HIV pathogenesis termed bystander cell death.
H, Garg, R, Blumenthal
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