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Biochimica Et Biophysica Acta - Molecular Cell Research, 2003 The secretory process requires many different steps and stages. Vesicles must be formed and transported to the target membrane. They must be tethered or docked at the appropriate sites and must be prepared for fusion (priming). As the last step, a fusion
Guillermo Alvarez de Toledo +1 more
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Vesicle cholesterol controls exocytotic fusion pore [PDF]
Cell Calcium, 2022 In some lysosomal storage diseases (LSD) cholesterol accumulates in vesicles. Whether increased vesicle cholesterol affects vesicle fusion with the plasmalemma, where the fusion pore, a channel between the vesicle lumen and the extracellular space, is ...
Frances M Platt +2 more
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Phases of the exocytotic fusion pore [PDF]
FEBS Letters, 2018 Membrane fusion and fission are fundamental processes in living organisms. Membrane fusion occurs through the formation of a fusion pore, which is the structure that connects two lipid membranes during their fusion. Fusion pores can form spontaneously, but cells endow themselves with a set of proteins that make the process of fusion faster and ...
Guillermo Alvarez de Toledo +1 more
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Fusion pore regulation in peptidergic vesicles
Cell Calcium, 2012Regulated exocytosis, which involves fusion of secretory vesicles with the plasma membrane, is an important mode of communication between cells. In this process, signalling molecules that are stored in secretory vesicles are released into the extracellular space.
Nina Vardjan +2 more
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Fusion pore stability of peptidergic vesicles
Molecular Membrane Biology, 2010It is believed that in regulated exocytosis the vesicle membrane fuses with the plasma membrane in response to a physiological stimulus. However, in the absence of stimulation, repetitive transient fusion events are also observed, reflecting a stable state. The mechanisms by which the initial fusion pore attains stability are poorly understood.
Nina Vardjan +2 more
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Mechanics of membrane fusion/pore formation
Chemistry and Physics of Lipids, 2015 Lipid bilayers play a fundamental role in many biological processes, and a considerable effort has been invested in understanding their behavior and the mechanism of topological changes like fusion and pore formation. Due to the time- and length-scale on which these processes occur, computational methods have proven to be an especially useful tool in ...
Marcus Müller, Marc Fuhrmans
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Fusion Pores, SNAREs, and Exocytosis
The Neuroscientist, 2012Exocytosis is a multistage process involving a merger between the vesicle and the plasma membranes, leading to the formation of a fusion pore, a channel, through which secretions are released from the vesicle to the cell exterior. A stimulus may influence the pore by either dilating it completely (full-fusion exocytosis) or mediating a reversible ...
Nina, Vardjan +2 more
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The fusion pore and mechanisms of biological membrane fusion
Current Opinion in Cell Biology, 1996Membrane fusion occurs as part of processes as different as synaptic neurotransmitter transmission and infection with influenza virus. Recent evidence paints a picture in which the organization of proteins into a macromolecular scaffold brings the two fusing membranes together and induces hemifusion, that is, the fusion of the apposing leaflets of the ...
J R, Monck, J M, Fernandez
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Fusion pore regulation of transmitter release
Brain Research Reviews, 2005During the last decade a wealth of new information about the properties of the exocytotic fusion pore is changing our current view of exocytosis. The exocytotic fusion pore, a necessary stage before the full merging of the vesicle membrane with the plasma membrane, is becoming a key cellular structure that might critically control the amount of ...
Carlos, Fernández-Peruchena +3 more
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Exocytotic fusion pores as a target for therapy
Cell Calcium, 2017Regulated exocytosis can be split into a sequence of steps ending with the formation and the dilation of a fusion pore, a neck-like connection between the vesicle and the plasma membrane. Each of these steps is precisely controlled to achieve the optimal spatial and temporal profile of the release of signalling molecules.
Jernej, Jorgačevski +2 more
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