Results 251 to 260 of about 1,288,108 (273)
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Physiology, 2002
Earlier electrophysiological measurements on live secretory cells suggested the presence of fusion pores at the plasma membrane, where secretory vesicles fuse to release vesicular contents. Recent studies using atomic force microscopy demonstrate for the first time the presence of the fusion pore and reveal its morphology and dynamics at near ...
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Earlier electrophysiological measurements on live secretory cells suggested the presence of fusion pores at the plasma membrane, where secretory vesicles fuse to release vesicular contents. Recent studies using atomic force microscopy demonstrate for the first time the presence of the fusion pore and reveal its morphology and dynamics at near ...
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The exocytotic fusion pore and neurotransmitter release
Neuron, 1994Membrane fusion is ubiquitous in biological systems, occurring in the simplest of unicellular eukaryotes as well as higher eukaryotes. As soon as the first primitive eukaryotic cell utilized a lipid bilayer as an outer membrane, membrane fusion (and fission) became necessary for the traffic of material from the outside to the inside, the inside to the ...
J R, Monck, J M, Fernandez
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Conflicting Views on the Membrane Fusion Machinery and the Fusion Pore
Annual Review of Cell and Developmental Biology, 2009Fast exocytosis of synaptic vesicles differs from other membrane fusion reactions by being under tight temporal control by the intracellular calcium concentration. This is achieved by subjecting the SNARE-dependent fusion pathway to additional layers of control, both upstream and downstream of the assembly of the fusogenic SNARE-complex.
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FUSION PORES AND FUSION MACHINES IN CA2+-TRIGGERED EXOCYTOSIS
Annual Review of Biophysics and Biomolecular Structure, 2006Exocytosis is initiated within a highly localized region of contact between two biological membranes. Small areas of these membranes draw close, molecules on the two surfaces interact, and structural transformations take place. Membrane fusion requires the action of proteins specialized for this task, and these proteins act as a fusion machine.
Meyer B, Jackson, Edwin R, Chapman
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The Fusion Pore and Vesicle Cargo Discharge Modulation
Annals of the New York Academy of Sciences, 2009Exocytosis, the merger of the vesicle membrane with the plasma membrane, is thought to mediate the release of hormones and neurotransmitters from secretory vesicles. The work of Bernard Katz and colleagues decades ago considered that vesicle cargo discharge initially requires the delivery of secretory vesicles to the plasma membrane where vesicles dock
Nina, Vardjan +5 more
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The fusion pore interface: a new biological frontier
Current Opinion in Neurobiology, 1994The development of micro-voltammetry to detect the release of secretory products from single cells has yielded surprising information, which suggests that the release of secretory products is regulated after the fusion of secretory vesicles with the plasma membrane. This technique has also been used to demonstrate that the release of secretory products
Robinson, Iain M., Fernandez, Julio M.
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Science's STKE, 2004
The fusion pore for exocytosis, which can be defined biophysically, can be modulated by synaptotagmin, a protein found on synaptic vesicles. However, the nature of the fusion pore itself remains unclear. It is not even known whether the fusion pore is composed of lipid or protein. Han et al .
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The fusion pore for exocytosis, which can be defined biophysically, can be modulated by synaptotagmin, a protein found on synaptic vesicles. However, the nature of the fusion pore itself remains unclear. It is not even known whether the fusion pore is composed of lipid or protein. Han et al .
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Mechanisms of Fusion Protein Transmembrane Segments in Fusion Pore Formation
ChemBioChemSoluble N‐ethylmaleimide‐sensitive factor attachment protein receptors (SNAREs) are essential for membrane fusion, yet the mechanistic role of their transmembrane domains (TMDs) remains debated. Here, we use molecular dynamics simulations of a synaptic vesicle and a planar plasma membrane to elucidate how the aggregation state and copy number of SNAREs
Jie Liu +6 more
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Interactions of peptides with liposomes: pore formation and fusion
Progress in Lipid Research, 2000Leakage from liposomes induced by several peptides is reviewed and a pore model is described. According to this model peptide molecules become incorporated into the vesicle bilayer and aggregate reversibly or irreversibly within the surface. When a peptide aggregate reaches a critical size, peptide translocation can occur and a pore is formed. With the
S, Nir, J L, Nieva
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