Results 71 to 80 of about 19,722 (182)

Nanotechnology in Hematology: Enhancing Therapeutic Efficacy With Nanoparticles

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Hematological malignancies, such as leukemia, lymphoma, and multiple myeloma, contribute significantly to global cancer diagnoses. Despite progress in conventional therapies, such as chemotherapy and immunotherapy, these treatments face limitations, including nonspecific targeting, side effects, and drug resistance. The aim
Nima Torabi Fard, Melika Khademi, Aryan Salahi‐Niri, Shadi Esmaeili   +3 more
wiley   +1 more source

α‐Synuclein in Parkinson's Disease: From Bench to Bedside

Medicinal Research Reviews, Volume 45, Issue 3, Page 909-946, May 2025.
ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging element at the crossroads between neuro/immune‐inflammatory responses and neurodegeneration in PD. Several evidence show that pathological α‐syn accumulates in neuronal and non‐neuronal cells (i.e., neurons, microglia, macrophages, skin cells, and intestinal cells ...
Gabriele Bellini, Vanessa D'Antongiovanni, Giovanni Palermo, Luca Antonioli, Matteo Fornai, Roberto Ceravolo, Nunzia Bernardini, Pascal Derkinderen, Carolina Pellegrini   +8 more
wiley   +1 more source

RNA‐sequencing: A reliable tool to unveil transcriptional landscape of paediatric B‐other acute lymphoblastic leukaemia

British Journal of Haematology, Volume 206, Issue 5, Page 1355-1365, May 2025.
Using current standard‐of‐care tests used in clinical practice, 20%–30% of B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) patients remain unclassified. These patients are grouped into a heterogeneous category named B‐other ALL and are all treated with the same intensity. The application of RNA‐seq, together with the integration of standard‐of‐
Clara Vicente‐Garcés, Guerau Fernández, Elena Esperanza‐Cebollada, Mercè Richarte‐Franqués, Alba Crespo‐Carrasco, Sara Montesdeoca, Ignacio Isola, Edurne Sarrate, Esther Cuatrecasas, Susana Rives, José Luis Dapena, Mireia Camós, Nerea Vega‐García   +12 more
wiley   +1 more source

Evaluation of a new flow cytometry based method for detection of BCR-ABL1 fusion protein in chronic myeloid leukemia

Blood Research, 2017
Background Philadelphia chromosome, a hallmark of chronic myeloid leukemia (CML), plays a key role in disease pathogenesis. It reflects a balanced reciprocal translocation between long arms of chromosomes 9 and 22 involving BCR and ABL1 genes ...
S. Dasgupta, U. Ray, A. G. Mitra, D. Bhattacharyya, A. Mukhopadhyay, P. Das, S. Gangopadhyay, S. Roy, S. Mukhopadhyay   +8 more
semanticscholar   +1 more source

Self-assembled Human Serum Protein-based Core-shell Nanoparticles to inhibit key oncogenic signalling in Drug-Resistant Leukemia

Precision Nanomedicine
Simultaneous inhibition of multiple oncogenic signaling pathways is crucial for managing refractory cancers. This study introduces two unique core-shell nanoparticle (CS-NP) systems crafted from natural proteins that simultaneously target two crucial ...
Archana Payickattu Retnakumary, Lekshmi G Kumar, Neeraj Sidharthan, Pavithran Keechilat, Giridharan L. Malarvizhi, Prasanna L Hanumanthu, Madhavan V Thampi, Deepthy Menon, Krishnakumar Menon, Shantikumar V Nair, Manzoor Koyakutty   +10 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript

Pakistan Journal of Medicine and Dentistry
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes ...
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin   +3 more
doaj  

Detection of p190BCR-ABL AND p210BCR-ABL fusion transcripts in patients with chronic myeloid leukemia (CML) using qualitative RT-PCR

Iatreia, 2014
Introduction: Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome (Ph), resulting from the balanced reciprocal translocation t(9;22)(q34;q11).
Aya Bonilla, Carlos Alberto , Domingo Torres, José , Muskus, Carlos Enrique, Ramírez Gaviria, Gloria , Cuervo Sierra, Jorge , Sierra Sánchez, Margarita , Cuéllar-Ambrosi, Francisco , Botero Garcés, Jorge Humberto, Gloria Artigas A., Carmen , Muñetón, Carlos Mario , Vásquez Palacio, Gonzalo   +10 more
doaj  

Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer [PDF]

ACS Medicinal Chemistry Letters, 2020
openaire   +3 more sources

Acute lymphoblastic leukemia with e1A3 BCR-ABL fusion protein: report of 2 cases and literature review

Di-san junyi daxue xuebao, 2021
Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ hybridization (FISH) and real-time fluorescence quantitative PCR of 2 ALL cases with e1a3 BCR-ABL ...
CHEN Siyu, DENG Xiaojuan, ZHANG Yuwei, GOU Yang, ZHANG Xi, PENG Xiangui, WANG Ping   +6 more
openaire   +1 more source