Results 81 to 90 of about 20,944 (184)
Molecular mechanisms in haematological malignancies [PDF]
, 2009 Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto +2 more
core
Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma [PDF]
, 2010 We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript.
Jakovljević, Gordana +6 more
core +1 more source
Nanosensors in Leukemia Management: Pioneering Real‐Time Biomarker Detection for Precision Oncology
Nano Select, Volume 6, Issue 12, December 2025.This review highlights pioneering nanosensors designed for real‐time leukemia biomarker detection, integrating advanced nanomaterials such as liposomes, polymeric nanoparticles and quantum dots. It examines electrochemical, optical and magnetic detection mechanisms, the applications across AML, ALL, CML, and CLL subtypes, and clinical translation ...
Hamed Soleimani Samarkhazan +5 more
wiley +1 more source
The role of miRNA in haematological malignancy [PDF]
, 2013 Currently, there are over 1,800 annotated human miRNAs, many of which have tissue-specific expression. Numerous studies have highlighted their role in haematopoietic differentiation and proliferation, acting as master regulators of haematopoietic stem ...
Chevassut, Timothy +1 more
core +2 more sources
Di-san junyi daxue xuebao, 2021 Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ hybridization (FISH) and real-time fluorescence quantitative PCR of 2 ALL cases with e1a3 BCR-ABL ...
CHEN Siyu +6 more
openaire +1 more source
Metabolic gatekeeper function of B-lymphoid transcription factors. [PDF]
, 2017 B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of pre-B-cell acute lymphoblastic leukaemia (ALL).
Borkhardt, Arndt +26 more
core
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
ChiPPI: a novel method for mapping chimeric protein–protein interactions uncovers selection principles of protein fusion events in cancer [PDF]
, 2017 Fusion proteins, comprising peptides deriving from the translation of two parental genes, are produced in cancer by chromosomal aberrations. The expressed fusion protein incorporates domains of both parental proteins.
Frenkel-Morgenstern, Milana +5 more
core +3 more sources
Lipidome Plasticity Preserves Membrane Function in Sphingolipid‐Depleted HAP1 Cells
The FASEB Journal, Volume 39, Issue 22, 30 November 2025.Near‐haploid HAP1‐SPT cells, which cannot synthesize sphingolipids de novo, undergo a drastic reduction in sphingolipid content when grown under low FBS conditions. To compensate, they remodel their lipidome by increasing ether‐linked phospholipids and adjusting glycerophospholipid saturation.
Bingen G. Monasterio +5 more
wiley +1 more source