Results 1 to 10 of about 5,080 (131)

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors [PDF]

Cancer Medicine
Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis ...
Kayla Bastian, Margarita Orozco‐Moreno, Huw Thomas, Kirsty Hodgson, Eline A. Visser, Emiel Rossing, Johan F. A. Pijnenborg, Nienke Eerden, Laura Wilson, Hasvini Saravannan, Oliver Hanley, Grace Grimsley, Fiona Frame, Ziqian Peng, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Norman J. Maitland, Rakesh Heer, Ning Wang, Ethan D. Goddard‐Borger, Ramon Hurtado Guerrero, Thomas J. Boltje, Richard R. Drake, Emma Scott, David J. Elliott, Jennifer Munkley   +28 more
doaj   +4 more sources

Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling [PDF]

International Dental Journal
Background: Chronic inflammation in periodontitis is linked to aberrant glycosylation, yet the molecular mechanisms and therapeutic potential of the core fucosyltransferase Fut8 remain undefined.
Jiahao Lin, Yongxi Luo, Lu Chen, Cheng Zeng, Lu Wang, Xinmiao Luo, Li Zeng, Huiyong Xu, Zhao Chen   +8 more
doaj   +2 more sources

Identification of hub gene associated with colorectal cancer: Integrating Mendelian randomization, transcriptome analysis and experimental verification. [PDF]

PLoS Genetics
BackgroundColorectal cancer (CRC) is a prevalent malignancy with significant mortality rates globally. Understanding the genetic and molecular mechanisms underlying CRC development is crucial for improving therapeutic strategies.MethodIn this study, we ...
Yu Zhang, Xu Han, Yichun Yang, Jiayan Ren, Zixi Zhang, Yanmin Zhang, Qi Su, Dake Chu   +7 more
doaj   +2 more sources

Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0 [PDF]

BMC Biotechnology, 2011
Background The rat hybridoma cell line YB2/0 appears a good candidate for the large-scale production of low fucose recombinant mAbs due to its lower expression of fut8 gene than other commonly used rodent cell lines.
Harduin-Lepers Anne, Bobowski Marie, Meurice Edwige, Teylaert Béatrice, Gaucher Christine, Fontayne Alexandre, Jorieux Sylvie, Delannoy Philippe   +7 more
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Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma. [PDF]

PLoS ONE
Lung cancer remains the leading cause of malignant tumors worldwide in terms of the incidence and mortality, posing a significant threat to human health.
Zhijun Li, Zhenpeng Zhu, Peng Wang, Chenyang Hou, Lijuan Ren, Dandan Xu, Xiran Wang, Fei Guo, Qingxue Meng, Weizheng Liang, Jun Xue, Xuejun Zhi   +11 more
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Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression [PDF]

Nature Communications
Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang, Dongyang He, Mengyu Ke, Jinhua Qin, Guang Yang, Biao Yu, Jing Wang, Pengfei Fang   +7 more
doaj   +2 more sources

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion [PDF]

Advanced Science
Glycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
doaj   +2 more sources

Analysis of L1 Cell Adhesion Molecule and Fucosyltransferase 8 Expression in Cells After Stretch and Human EACSCC Tissue [PDF]

Journal of International Advanced Otology
Background: External auditory canal (EAC) squamous cell carcinoma (SCC) is classified as a rare cancer and has a poor prognosis at advanced stages. Mechanical stress has been implicated in external auditory canal squamous cell carcinoma (EACSCC), but the
Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Hiromi Kojima   +2 more
doaj   +2 more sources

Roles of core fucosylation modification in immune system and diseases [PDF]

Cell Insight
Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals.
Qiu Pan, Xiao-Lian Zhang
doaj   +2 more sources

Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts [PDF]

PeerJ, 2021
Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Zhiming Wu, Tianye Lin, Pan Kang, Zhikun Zhuang, Haibin Wang, Wei He, Qiushi Wei, Ziqi Li   +7 more
doaj   +2 more sources