Results 61 to 70 of about 5,149 (183)

Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity

Frontiers in Immunology, 2022
Most of the membrane molecules involved in immune response are glycosylated. N-glycans linked to asparagine (Asn) of immune molecules contribute to the protein conformation, surface expression, stability, and antigenicity.
Yuhan Sun, Yuhan Sun, Xueying Li, Tiantong Wang, Wenzhe Li   +4 more
doaj   +1 more source

Genome-wide association study identifies _FUT8_ and _ESR2_ as co-regulators of a bi-antennary N-linked glycan A2 (GlcNAc~2~Man~3~GlcNAc~2~) in human plasma proteins [PDF]

, 2009
HPLC analysis of N-glycans quantified levels of the biantennary glycan (A2) in plasma proteins of 924 individuals. Subsequent genome-wide association study (GWAS) using 317,503 single nucleotide polymorphysms (SNP) identified two genetic loci influencing
Alan F. Wright, Ana Knezevic, Caroline Hayward, Gordan Lauc, Harry Campbell, Igor Rudan, Ivana Kolcic, Jennifer Huffman, Lina Zgaga, Nicholas D. Hastie, Olga Gornik, Ozren Polasek, Pauline M. Rudd, Veronique Vitart, Zrinka Biloglav   +14 more
core   +1 more source

Sequential, chromosome‐specific glutamine synthetase double knockout with Cas‐CLOVER establishes enhanced CHO platforms for cell line development

Biotechnology Progress, EarlyView.
This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia, Valeriya Steffey, Hsueh Che Cheng, Daniel Machado, Thomas Hart, Mark Cameron McHargue, Corey Brizzee, Jack Crawford   +7 more
wiley   +1 more source

Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL. [PDF]

Oncogenesis
Diffuse large B-cell lymphoma (DLBCL) is characterized by its aggressive nature and resistance to standard chemotherapy, necessitating the development of new therapeutic approaches. The emergence of natural products and their derivatives has notably influenced cancer treatment, making morusinol, a medicine-derived monomer, a promising candidate.
Xu H, Li Q, Zhang Y, He C, Zhang X, Wang Z, Zhao M, Chai Y, Zhuang W, Li B.   +9 more
europepmc   +3 more sources

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation [PDF]

, 2017
Joint modeling of a number of phenotypes using multivariate methods has often been neglected in genome-wide association studies and if used, replication has not been sought. Modern omics technologies allow characterization of functional phenomena using a
Aulchenko, Yurii S., Hayward, Caroline, Klarić, Lucija, Lauc, Gordan, Mangino, Massimo, Ning, Zheng, Polasek, Ozren, Pučić-Baković, Maja, Rudan, Igor, Sharapov, Sodbo, Shen, Xia, Spector, Tim D, Trbojević-Akmačić, Irena, Wilson, James F., Wu, Di   +14 more
core   +4 more sources

Appropriate aglycone modification significantly expands the glycan substrate acceptability of α1,6-fucosyltransferase (FUT8)

Biochemical Journal, 2021
The α1,6-fucosyltransferase, FUT8, is the sole enzyme catalyzing the core-fucosylation of N-glycoproteins in mammalian systems. Previous studies using free N-glycans as acceptor substrates indicated that a terminal β1,2-GlcNAc moiety on the Man-α1,3-Man arm of N-glycan substrates is required for efficient FUT8-catalyzed core-fucosylation.
Roushu Zhang, Qiang Yang, Bhargavi M. Boruah, Guanghui Zong, Chao Li, Digantkumar Chapla, Jeong-Yeh Yang, Kelley W. Moremen, Lai-Xi Wang   +8 more
openaire   +2 more sources

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses

Nature Communications
Aberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis.
Qiu Pan, Yan Xie, Ying Zhang, Xinqi Guo, Jing Wang, Min Liu, Xiao-Lian Zhang   +6 more
doaj   +1 more source

Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation [PDF]

The American Journal of Human Genetics, 2018
Fucosyltransferase 8 (FUT8) encodes a Golgi-localized α1,6 fucosyltransferase that is essential for transferring the monosaccharide fucose into N-linked glycoproteins, a process known as "core fucosylation." Here we describe three unrelated individuals, who presented with intrauterine growth retardation, severe developmental and growth delays with ...
Ng, Bobby G, Xu, Gege, Chandy, Nandini, Steyermark, Joan, Shinde, Deepali N, Radtke, Kelly, Raymond, Kimiyo, Lebrilla, Carlito B, AlAsmari, Ali, Suchy, Sharon F, Powis, Zöe, Faqeih, Eissa Ali, Berry, Susan A, Kronn, David F, Freeze, Hudson H   +14 more
openaire   +4 more sources

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source