Results 11 to 20 of about 518,372 (264)
eLife, 2015 Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin.
Anthony W Azevedo +10 more
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A G-Protein Coupled Receptor and Macular Degeneration
Cells, 2020 Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the world. The risk of AMD increases with age and is most common among the white population. Here, we discuss the convergence of factors related to race, pigmentation,
Anna G. Figueroa, Brian S. McKay
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G-Protein-Coupled Receptors [PDF]
Journal of Biological Chemistry, 1998 G-protein-coupled receptors (GPCRs) constitute a huge family of membrane receptors to numerous hormones, neurotransmitters and diverse compounds. A large part of cardiovascular and neurological pharmacology is based upon the knowledge of these receptors and on the identification of molecules able to interfere with them, in an agonistic or antagonistic ...
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Regulation Role of Non-Rhodopsin G Protein-coupled Receptor Kinases on Tumor
Zhongliu Fangzhi Yanjiu, 2019 G protein-coupled receptor kinases (GRKs) are involved in a wide range of cellular physiology and pathological activities by specifically phosphorylating activated G-protein coupled receptors (GPCRs) to terminate GPCR signaling and phosphorylating non ...
LI Ruirui, JIANG Xiaoshan
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Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast
Biomolecules, 2022 The yeast Saccharomyces cerevisiae has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about the receptors and signaling pathways that indicate glucose availability.
Shuang Li +7 more
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REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors
Biosensors, 2023 Despite G protein-coupled receptors (GPCRs) being important theapeutic targets, the signaling properties of many GPCRs remain poorly characterized. GPCR activation primarily initiates heterotrimeric G protein signaling. To detect ligand-induced G protein
Katrijn Boon +4 more
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Journal of Diabetes Investigation, 2019 Aims/Introduction Incretin hormone glucose‐dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) plays a key role in high‐fat diet‐induced obesity and insulin resistance.
Akiko Sankoda +8 more
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Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure
Cell Reports, 2017 The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors.
James H. Felce +7 more
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Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein
MedComm, 2022 GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye +10 more
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G‐protein‐coupled receptors and melanoma [PDF]
Pigment Cell & Melanoma Research, 2008 SummaryG‐protein‐coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over‐expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and ...
Hwa Jin, Lee, Brian, Wall, Suzie, Chen
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