Results 211 to 220 of about 518,372 (264)

Investigating the Structural Basis of Diacetyl Recognition by the G-Protein-Coupled Receptor ODR-10 in <i>Caenorhabditis elegans</i>. [PDF]

J Phys Chem B
Di Rienzo L, Milanetti E, Folli V, Ruocco G.   +3 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

This is not a G protein-coupled receptor

Trends in Pharmacological Sciences, 1993
On his canvas entitled 'La trahison des Images' ('The Perfidy of Images'), René Magritte painted a tobacco pipe in a very realistic manner and added the words: 'Ceci n'est pas une pipe' ('This is not a pipe'). In similar style, it is of prime importance to state that the first three-dimensional (3D) models of G protein-coupled receptors (GPCRs) that ...
M F, Hibert, S, Trumpp-Kallmeyer, J, Hoflack, A, Bruinvels   +3 more
openaire   +2 more sources

G protein-coupled receptors

Current Biology, 1992
The diversity of the G protein-coupled receptor superfamily is now being realised with the molecular cloning of DNA encoding many new receptors and receptor subfamilies. The existing pharmacological definitions of receptor subtypes have been extended dramatically with identification of additional subtypes at the molecular level.
T P, Iismaa, J, Shine
openaire   +2 more sources

G-Protein-Coupled Receptors

2008
G-Protein-coupled receptors mediate many of the hypnotic and analgesic actions of the drugs employed in anesthesia. Notably, opioid agonists represent the most successful and efficacious class of analgesic agents employed over the last century. Also, major clinical advances have been made by the study of alpha(2) adrenoceptor agonists, which possess ...
R D, Sanders, D, Brian, M, Maze
openaire   +2 more sources

Dimerization of G-Protein-Coupled Receptors

Journal of Medicinal Chemistry, 2001
The evolutionary trace (ET) method, a data mining approach for determining significant levels of amino acid conservation, has been applied to over 700 aligned G-protein-coupled receptor (GPCR) sequences. The method predicted the occurrence of functionally important clusters of residues on the external faces of helices 5 and 6 for each family or ...
M K, Dean, C, Higgs, R E, Smith, R P, Bywater, C R, Snell, P D, Scott, G J, Upton, T J, Howe, C A, Reynolds   +8 more
openaire   +2 more sources

Pharmacogenetics of the G Protein-Coupled Receptors

2014
Pharmacogenetics investigates the influence of genetic variants on physiological phenotypes related to drug response and disease, while pharmacogenomics takes a genome-wide approach to advancing this knowledge. Both play an important role in identifying responders and nonresponders to medication, avoiding adverse drug reactions, and optimizing drug ...
M. D. Thompson, D. E. C. Cole, V. Capra, K. A. Siminovitch, G.E. Rovati, W. M. Burnham, B. K. Rana   +6 more
openaire   +2 more sources

Efficacy at g-protein-coupled receptors

Nature Reviews Drug Discovery, 2002
At present, the drug-discovery process centres on ligands that either block or produce physiological responses. However, there are therapeutic uses for ligands that do neither of these things, but which still affect receptors in other ways. This review discusses the intimate relationship between the affinity of a ligand for its receptor, and the ...
openaire   +2 more sources

G protein-coupled receptors in rheumatology

Nature Reviews Rheumatology, 2014
G protein-coupled receptors (GPCRs) are transmembrane receptor proteins that allow the transfer of signals across the cell membrane. In addition to their physiological role, GPCRs are involved in many pathophysiological processes including pathways relevant in rheumatoid arthritis (RA), osteoarthritis (OA) and psoriatic arthritis.
Elena, Neumann, Kiran, Khawaja, Ulf, Müller-Ladner   +2 more
openaire   +2 more sources