Results 221 to 230 of about 518,372 (264)

Palmitoylation and G-protein coupled receptors

2022
More and more it is being appreciated that not all GPCRs are the same, sub-populations of GPCRs exist within a cell and function differently than others. The question is, how does one regulate a given sub-population? One way is through the addition of post-translational modifications to G-protein coupled receptors (GPCR).
Georges, Chalhoub, Peter J, McCormick
openaire   +2 more sources

G-protein-coupled receptors and cancer

Nature Reviews Cancer, 2007
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply ...
Robert T, Dorsam, J Silvio, Gutkind
openaire   +2 more sources

Deorphanization of G-Protein-Coupled Receptors

2007
G-protein-coupled receptors constitute one of the major families of drug targets. Orphan receptors, for which the ligands and function are still unknown, are an attractive set of future targets for presently unmet medical needs. Screening strategies have been developed over the years in order to identify the natural ligands of these receptors.
Parmentier, Marc, Detheux, Michel
openaire   +3 more sources

G Protein-Coupled Receptor Pharmacogenetics

2008
Common G protein-coupled receptor (GPCR) gene variants that encode receptor proteins with a distinct sequence may alter drug efficacy without always resulting in a disease phenotype. GPCR genetic loci harbor numerous variants, such as DNA insertions or deletions and single-nucleotide polymorphisms that alter GPCR expression and function, thereby ...
Miles D, Thompson, Katherine A, Siminovitch, David E C, Cole   +2 more
openaire   +2 more sources

Ubiquitination of G-Protein-Coupled Receptors

2004
In this chapter we describe methods for detecting the ubiquitination state of G-protein-coupled receptors (GPCRs). This involves coexpression of a GPCR with an epitope-tagged ubiquitin construct in a heterologous expression system. Modification by ubiquitin of the GPCR resulting from agonist activation is detected by immunoprecipation and subsequent ...
Adriano, Marchese, Jeffrey L, Benovic
openaire   +2 more sources

G‐protein‐coupled receptors: an update

Acta Physiologica, 2007
Abstract The receptors that couple to G proteins (GPCR) and which span the cell membranes seven times (7‐TM receptors) were the focus of a symposium in Stockholm 2006. The ensemble of GPCR has now been mapped in several animal species. They remain a major focus of interest in drug development, and their diverse physiological and pathophysiological ...
B B, Fredholm, T, Hökfelt, G, Milligan
openaire   +2 more sources

G‐Protein–Coupled Receptor Deorphanizations

2005
G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend.
Yumiko, Saito, Olivier, Civelli
openaire   +2 more sources

G Protein‐Coupled Receptor Kinases

Journal of Neurochemistry, 1994
T, Haga, K, Haga, K, Kameyama
openaire   +2 more sources

G-Protein-Coupled Receptors

2006
S.B. Liggett, D.W. McGraw
openaire   +1 more source

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility

Trends in Cell Biology, 2020
Laura Wingler
exaly