Results 31 to 40 of about 503,639 (262)
Neuropeptide G Protein-Coupled Receptors as Oncotargets
Frontiers in Endocrinology, 2018 Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they
Terry W. Moody +2 more
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Role of G-protein coupled receptors in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2023 Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li +4 more
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G-protein coupled receptor structure
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 Because of their central role in regulation of cellular function, structure/function relationships for G-protein coupled receptors (GPCR) are of vital importance, yet only recently have sufficient data been obtained to begin mapping those relationships. GPCRs regulate a wide range of cellular processes, including the senses of taste, smell, and vision,
Philip L. Yeagle, Arlene D. Albert
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Regulating G protein-coupled receptors by topological inversion
eLife, 2019 G protein-coupled receptors (GPCRs) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular space and cytosol, respectively.
Bray Denard +4 more
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Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases
Cells, 2021 G protein-coupled receptors (GPCRs) have originally been described as a family of receptors activated by hormones, neurotransmitters, and other mediators.
Derek Strassheim +8 more
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G-Protein coupled receptors: answers from simulations
Beilstein Journal of Organic Chemistry, 2017 Molecular-dynamics (MD) simulations are playing an increasingly important role in research into the modes of action of G-protein coupled receptors (GPCRs).
Timothy Clark
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Peptide ligand recognition by G protein-coupled receptors
Frontiers in Pharmacology, 2015 The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
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G-protein-coupled receptor kinases
Kidney International, 1996 beta-Adrenergic receptors are prototypes of the many G-protein-coupled receptors. Activation and inactivation of these receptors are regulated by multiple mechanisms which can affect either their function or their expression. The most obvious changes of such receptor systems are induced by activation of the receptors themselves by their respective ...
Federico Mayor +3 more
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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
British Journal of Pharmacology, 2019 The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where ...
Stephen P. H. Alexander +13 more
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Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors
The Scientific World Journal, 2006 Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathways to ...
Nicholas Young, James R. Van Brocklyn
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