Results 11 to 20 of about 14,208,503 (293)
G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]
Pharmaceuticals, 2021 Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands.
Tiago Santos +3 more
semanticscholar +5 more sources
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders [PDF]
Nucleic Acids Research, 2020 Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held together by Hoogsteen hydrogen bonds and can form at key regulatory sites of ...
G. Miglietta, Marco Russo, G. Capranico
semanticscholar +4 more sources
Sequence determinants of RNA G-quadruplex unfolding by Arg-rich regions. [PDF]
FEBS LettWe show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
De Silva NIU +10 more
europepmc +2 more sources
G‐Quadruplex Nucleic Acids [PDF]
Journal of Nucleic Acids, 2010 2 pages.-- PMID: 20814544 [PubMed].-- PMCID: PMC2931383].
ERITJA R. +4 more
openaire +5 more sources
Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space
Pharmaceuticals, 2022 The structural polymorphism of G-quadruplex nucleic acids is an important factor in their recognition by proteins and small-molecule ligands. However, it is not clear why the binding of several ligands alters G-quadruplex topology.
Domen Oblak +3 more
doaj +1 more source
Stress promotes RNA G-quadruplex folding in human cells
bioRxiv, 2022 Guanine (G)-rich nucleic acids can fold into G-quadruplex (G4) structures under permissive conditions. Although many RNAs contain sequences that fold into RNA G4s (rG4s) in vitro, their folding and functions in vivo are not well understood.
Prakash Kharel +6 more
semanticscholar +1 more source
Heliyon, 2023 G-quadruplex, a structurally unique structure in nucleic acids present all throughout the human genome, has sparked great attention in therapeutic investigations. Targeting G-quadruplex structure is a new strategy for the drug development. Flavonoids are
Sagar Bag +2 more
doaj +1 more source
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
Nature Communications, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules,
Geng Liu +11 more
semanticscholar +1 more source
Microbiology Spectrum, 2022 Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
doaj +1 more source
RNA G-quadruplex structure contributes to cold adaptation in plants
bioRxiv, 2022 Nucleotide composition is suggested to infer gene functionality and ecological adaptation of species to distinct environments. However, the underlying biological function of nucleotide composition dictating environmental adaptations is largely unknown ...
Xiaofei Yang +9 more
semanticscholar +1 more source