Results 11 to 20 of about 12,561,590 (387)

G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions [PDF]

Pharmaceuticals, 2021
Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands.
Tiago Santos, G. Salgado, E. Cabrita, C. Cruz   +3 more
semanticscholar   +5 more sources

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

Nucleic Acids Research, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +4 more sources

G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders [PDF]

Nucleic Acids Research, 2020
Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held together by Hoogsteen hydrogen bonds and can form at key regulatory sites of ...
G. Miglietta, Marco Russo, G. Capranico
semanticscholar   +4 more sources

Isothermal folding of G-quadruplexes [PDF]

Methods, 2012
Thermodynamic studies of G-quadruplex stability are an essential complement to structures obtained by NMR or x-ray crystallography. An understanding of the energetics of quadruplex folding provides a necessary foundation for the physical interpretation ...
Antonacci, Balasubramanian, Burge, Catell, Chaires, Collie, Dai, Darby, De Cian, DeSa, Draper, Draper, Eddy, Eddy, Gray, Gray, Gray, Gray, Grilley, Haider, Haq, Hendler, Henry, Holt, Huppert, Huppert, Huppert, Huppert, Jonathan B. Chaires, Keesey, Lane, Leipply, Lipps, Majhi, Manning, Mergny, Mergny, Minta, Neidle, Olsen, Parkinson, Patel, Phan, Rachwal, Record, Robert D. Gray, Sheardy, Yang   +47 more
core   +4 more sources

DNA G-quadruplex structures: more than simple roadblocks to transcription?

Nucleic Acids Research, 2021
It has been >20 years since the formation of G-quadruplex (G4) secondary structures in gene promoters was first linked to the regulation of gene expression.
Jenna Robinson, Federica Raguseo, Sabrina Pia Nuccio, Denise Liano, M. Di Antonio   +4 more
semanticscholar   +1 more source

DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting.

Accounts of Chemical Research, 2022
ConspectusDNA G-quadruplex secondary structures formed in guanine-rich human telomeres and oncogene promoters are functionally important and have emerged as a promising new class of cancer-specific drug targets.
Luying Chen, J. Dickerhoff, S. Sakai, Danzhou Yang   +3 more
semanticscholar   +1 more source

Stress promotes RNA G-quadruplex folding in human cells

bioRxiv, 2022
Guanine (G)-rich nucleic acids can fold into G-quadruplex (G4) structures under permissive conditions. Although many RNAs contain sequences that fold into RNA G4s (rG4s) in vitro, their folding and functions in vivo are not well understood.
Prakash Kharel, Marta M. Fay, E. V. Manasova, Paul Anderson, Aleksander V. Kurkin, Junjie U. Guo, P. Ivanov   +6 more
semanticscholar   +1 more source

G‐Quadruplex Nucleic Acids [PDF]

Journal of Nucleic Acids, 2010
2 pages.-- PMID: 20814544 [PubMed].-- PMCID: PMC2931383].
ERITJA R., MERGNY J. L., MONTESARCHIO, DANIELA, SPINDLER L., WEBBA DA SILVA M.   +4 more
openaire   +5 more sources

GW-2974 and SCH-442416 modulators of tyrosine kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA.

PLoS ONE, 2022
GW-2974 is a potent tyrosine kinase receptor inhibitor while SCH-442416 is a potent adenosine receptors' antagonist with high selectivity towards human adenosine A2A receptor over other adenosine receptors. The two compounds were reported to possess anti-
Alaa A Salem, Ismail A El Haty, Mohammad A Ghattas   +2 more
doaj   +2 more sources

Characterization of G-Quadruplexes in Enterovirus A71 Genome and Their Interaction with G-Quadruplex Ligands

Microbiology Spectrum, 2022
Human enteroviruses cause many diseases; however, there is no specific therapeutic drug. G-quadruplex is an atypical secondary structure formed in the guanine rich region of DNA or RNA, which can exist in the viral genome.
Lu Lv, Leiliang Zhang
doaj   +1 more source