Results 1 to 10 of about 21,426,917 (362)
G-Protein–Coupled Receptors in Heart Disease
Circulation Research, 2018 GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of the largest class of surface receptors targeted by drugs.
Jialu Wang, C. Gareri, H. Rockman
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Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Nature Communications, 2018 Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological macromolecular complexes.
S. Maeda +9 more
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G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity
Redox Biology, 2021 Excessive ingestion of the common analgesic acetaminophen (APAP) leads to severe hepatotoxicity. Here we identify G protein β5 (Gβ5), elevated in livers from APAP overdose patients, as a critical regulator of cell death pathways and autophagic signaling ...
Arnab Pramanick +18 more
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Rubsicolins are naturally occurring G-protein-biased delta opioid receptor peptides
bioRxiv, 2018 The impact that β-arrestin proteins have on G-protein-coupled receptor trafficking, signaling and physiological behavior has gained much appreciation over the past decade.
Robert J. Cassell +6 more
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Therapeutic Advances in Infectious Disease, 2023 Background: Respiratory syncytial virus (RSV) is a poor inducer of antiviral interferon (IFN) responses which result in incomplete immunity and RSV disease.
Harrison C. Bergeron +2 more
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Heterotrimeric G Protein Signaling in Abiotic Stress
Plants, 2022 As sessile organisms, plants exhibit extraordinary plasticity and have evolved sophisticated mechanisms to adapt and mitigate the adverse effects of environmental fluctuations. Heterotrimeric G proteins (G proteins), composed of α, β, and γ subunits, are
Yijie Wang, Jose Ramón Botella
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, 2012 The classical view of heterotrimeric G protein signaling places G -proteins at the cytoplasmic surface of the cell's plasma membrane where they are activated by an appropriate G protein-coupled receptor. Once activated, the GTP-bound Gα and the free Gβγ are able to regulate plasma membrane-localized effectors, such as adenylyl cyclase, phospholipase C ...
openaire +2 more sources
Mutations in G proteins and G protein-coupled receptors in endocrine disease [PDF]
Journal of Clinical Endocrinology & Metabolism, 1996 Naturally occurring mutations in the G protein Gs-α subunit and in a number of G protein-coupled receptors (GPCRs) have been identified in human diseases. Such mutations may lead to loss or gain of function of the encoded protein. Study of such naturally occurring, disease-causing mutations offers unique insights into G protein and GPCR structure and ...
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Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins
Trends in Biochemical Sciences, 2015 G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and ...
Arnau Cordomí +5 more
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International Journal of Molecular Sciences, 2014 It has become increasingly apparent that the pain threshold of females and males varies in an estrogen dependent manner. To investigate the modulation of pain by estrogen and the molecular mechanisms involved in this process.
Guanghui An +3 more
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