Structural comparison of unconventional G protein YchF with heterotrimeric G protein and small G protein [PDF]
Plant Signaling & Behavior, 2022 Guanine nucleotide-binding (G) proteins, namely, phosphate-binding (P) loop GTPases, play a critical role in life processes among different species. Based on the structural characteristics, G proteins can be divided into heterotrimeric G proteins, small ...
Maozhen Luo +7 more
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The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]
Frontiers in Physiology, 2012 Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels.
Richard eAng +2 more
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G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding [PDF]
Signal Transduction and Targeted TherapyEvi Kostenis +2 more
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Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants
Disease Models & Mechanisms, 2022 Auriculocondylar syndrome 2 (ARCND2) is a rare autosomal dominant craniofacial malformation syndrome linked to multiple genetic variants in the coding sequence of phospholipase C β4 (PLCB4). PLCB4 is a direct signaling effector of the endothelin receptor
Stanley M. Kanai +9 more
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BSA nanoparticles loaded with IONPs for biomedical applications: fabrication optimization, physicochemical characterization and biocompatibility evaluation [PDF]
Nanomedicine Journal, 2019 Objective(s): Cancer diagnosis in its early stages of progress, can enhance the efficiency of treatment utilizing conventional therapy methods. Non-biocompatibility of iron oxide nanoparticles (IONPs) has made a big challenge against their usage as a ...
Parvin Najafi, Hasan Kouchakzadeh
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Medicine Science, 2022 Rabies is a viral disease caused by the rabies virus (Lyssavirus) that affects the central nervous system, ultimately leading to death and brain disease. Rabies usually transmitted through a bite among domestic dogs and wild carnivorous animals.
Gulshan Mammadova +6 more
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The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders [PDF]
Frontiers in Pharmacology, 2018 Progress toward new antidepressant therapies has been relatively slow over the past few decades, with the result that individuals suffering from depression often struggle to find an effective treatment - a process often requiring months. Furthermore, the neural factors that contribute to depression remain poorly understood, and there are many open ...
Nicolas B. Senese +6 more
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Structure-Guided Designing and Evaluation of Peptides Targeting Bacterial Transcription
Frontiers in Bioengineering and Biotechnology, 2020 The mycobacterial RNA polymerase (RNAP) is an essential and validated drug target for developing antibacterial drugs. The β-subunit of Mycobacterium tuberculosis (Mtb) RNAP (RpoB) interacts with an essential and global transcription factor, CarD, and ...
Gundeep Kaur +4 more
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eLife, 2020 The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets.
Eric M Jones +12 more
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The Evolution of Intein-Based Affinity Methods as Reflected in 30 years of Patent History
Frontiers in Molecular Biosciences, 2022 Self-cleaving affinity tags, based on engineered intein protein domains, have been touted as a universal single step purification platform for tagless non-mAb proteins.
Sai Vivek Prabhala +3 more
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