eLife, 2020 The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets.
Eric M Jones +12 more
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Structural comparison of unconventional G protein YchF with heterotrimeric G protein and small G protein [PDF]
Plant Signaling & Behavior, 2022 Guanine nucleotide-binding (G) proteins, namely, phosphate-binding (P) loop GTPases, play a critical role in life processes among different species. Based on the structural characteristics, G proteins can be divided into heterotrimeric G proteins, small ...
Maozhen Luo +7 more
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Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling. [PDF]
PLoS BiolSachdev S, Roy S, Cheloha RW.
europepmc +2 more sources
Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins. [PDF]
Cell Commun SignalGasser R +9 more
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Medicine Science, 2022 Rabies is a viral disease caused by the rabies virus (Lyssavirus) that affects the central nervous system, ultimately leading to death and brain disease. Rabies usually transmitted through a bite among domestic dogs and wild carnivorous animals.
Gulshan Mammadova +6 more
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BSA nanoparticles loaded with IONPs for biomedical applications: fabrication optimization, physicochemical characterization and biocompatibility evaluation [PDF]
Nanomedicine Journal, 2019 Objective(s): Cancer diagnosis in its early stages of progress, can enhance the efficiency of treatment utilizing conventional therapy methods. Non-biocompatibility of iron oxide nanoparticles (IONPs) has made a big challenge against their usage as a ...
Parvin Najafi, Hasan Kouchakzadeh
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Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants
Disease Models & Mechanisms, 2022 Auriculocondylar syndrome 2 (ARCND2) is a rare autosomal dominant craniofacial malformation syndrome linked to multiple genetic variants in the coding sequence of phospholipase C β4 (PLCB4). PLCB4 is a direct signaling effector of the endothelin receptor
Stanley M. Kanai +9 more
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Oncogene, 2001 Heterotrimeric guanine nucleotide binding proteins, commonly known as G proteins form a super-family of signal transduction proteins. They are peripherally associated with the plasma membrane and provide signal coupling to seven transmembrane surface receptors. G proteins are composed of monomers of alpha, beta, and gamma subunits.
V, Radhika, N, Dhanasekaran
openaire +2 more sources
Structure-Guided Designing and Evaluation of Peptides Targeting Bacterial Transcription
Frontiers in Bioengineering and Biotechnology, 2020 The mycobacterial RNA polymerase (RNAP) is an essential and validated drug target for developing antibacterial drugs. The β-subunit of Mycobacterium tuberculosis (Mtb) RNAP (RpoB) interacts with an essential and global transcription factor, CarD, and ...
Gundeep Kaur +4 more
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The Evolution of Intein-Based Affinity Methods as Reflected in 30 years of Patent History
Frontiers in Molecular Biosciences, 2022 Self-cleaving affinity tags, based on engineered intein protein domains, have been touted as a universal single step purification platform for tagless non-mAb proteins.
Sai Vivek Prabhala +3 more
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