Results 1 to 10 of about 21,180,380 (322)
Ligand and G-protein selectivity in the κ-opioid receptor
Nature, 2023 The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders^ 1 .
Jianming Han +13 more
semanticscholar +1 more source
Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants
Disease Models & Mechanisms, 2022 Auriculocondylar syndrome 2 (ARCND2) is a rare autosomal dominant craniofacial malformation syndrome linked to multiple genetic variants in the coding sequence of phospholipase C β4 (PLCB4). PLCB4 is a direct signaling effector of the endothelin receptor
Stanley M. Kanai +9 more
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective ...
Stephen P. H. Alexander +154 more
semanticscholar +1 more source
G protein-coupled receptors: structure- and function-based drug discovery
Signal Transduction and Targeted Therapy, 2021 As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design.
Dehua Yang +14 more
semanticscholar +1 more source
BSA nanoparticles loaded with IONPs for biomedical applications: fabrication optimization, physicochemical characterization and biocompatibility evaluation [PDF]
Nanomedicine Journal, 2019 Objective(s): Cancer diagnosis in its early stages of progress, can enhance the efficiency of treatment utilizing conventional therapy methods. Non-biocompatibility of iron oxide nanoparticles (IONPs) has made a big challenge against their usage as a ...
Parvin Najafi, Hasan Kouchakzadeh
doaj +1 more source
Medicine Science, 2022 Rabies is a viral disease caused by the rabies virus (Lyssavirus) that affects the central nervous system, ultimately leading to death and brain disease. Rabies usually transmitted through a bite among domestic dogs and wild carnivorous animals.
Gulshan Mammadova +6 more
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Structure-Guided Designing and Evaluation of Peptides Targeting Bacterial Transcription
Frontiers in Bioengineering and Biotechnology, 2020 The mycobacterial RNA polymerase (RNAP) is an essential and validated drug target for developing antibacterial drugs. The β-subunit of Mycobacterium tuberculosis (Mtb) RNAP (RpoB) interacts with an essential and global transcription factor, CarD, and ...
Gundeep Kaur +4 more
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G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding [PDF]
Signal Transduction and Targeted TherapyEvi Kostenis +2 more
doaj +2 more sources
eLife, 2020 The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets.
Eric M Jones +12 more
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The Evolution of Intein-Based Affinity Methods as Reflected in 30 years of Patent History
Frontiers in Molecular Biosciences, 2022 Self-cleaving affinity tags, based on engineered intein protein domains, have been touted as a universal single step purification platform for tagless non-mAb proteins.
Sai Vivek Prabhala +3 more
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