Results 11 to 20 of about 807,055 (385)
G Protein-Coupled Receptors in Taste Physiology and Pharmacology
Frontiers in Pharmacology, 2020 Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions.
Raise Ahmad, Julie E. Dalziel
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Frontiers in Cell and Developmental Biology, 2023 Introduction: G-protein coupled receptors (GPCRs) are the largest family of human receptors that transmit signals from natural ligands and pharmaceutical drugs into essentially every physiological process.
Siri Leemann, Sonja Kleinlogel
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective ...
Stephen P. H. Alexander +154 more
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G protein-coupled receptors: structure- and function-based drug discovery
Signal Transduction and Targeted Therapy, 2021 As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design.
Dehua Yang +14 more
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G-protein-coupled receptors at a glance [PDF]
Journal of Cell Science, 2003 [No abstract available]
Douglas J. Sheffler +2 more
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Royal Society Open Science, 2022 Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation.
Rebecca Claßen +4 more
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G Protein–Coupled Receptor Heteromers [PDF]
Annual Review of Pharmacology and Toxicology, 2016 G protein–coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling. They are involved in numerous physiological and pathological processes and are prime candidates for drug development. Over the past decade, an increasing number of studies have reported heteromerization between GPCRs.
Wakako Fujita +6 more
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Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. [PDF]
PLoS ONE, 2015 The purpose of this study was to evaluate the extent of constitutive activity among orphan class-A G protein coupled receptors within the cAMP signaling pathway.
Adam L Martin +2 more
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G Protein-Coupled Receptors in Cancer [PDF]
International Journal of Molecular Sciences, 2016 Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their downstream signaling targets in cancer growth and development.
Beatrice Uziely +6 more
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Rules and mechanisms governing G protein coupling selectivity of GPCRs
Cell Reports, 2023 Summary: G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13.
Ikuo Masuho +8 more
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