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FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
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Trends in Biochemical Sciences, 1992
The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits.
J R, Hepler, A G, Gilman
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The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits.
J R, Hepler, A G, Gilman
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Trends in Pharmacological Sciences, 1999
Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
M, Freissmuth +3 more
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Heterotrimeric G proteins couple membrane-bound heptahelical receptors to their cellular effector systems (ion channels or enzymes generating a second messenger). In current pharmacotherapy, the input to G protein-regulated signalling is typically manipulated by targeting the receptor with appropriate agonists or antagonists and, to a lesser extent, by
M, Freissmuth +3 more
openaire +2 more sources
The role of G protein conformation in receptor–G protein selectivity
Nature Chemical Biology, 2023G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear. Structural studies emphasize structural complementarity of GPCRs and nucleotide-free G proteins, but selectivity is likely to be determined by transient intermediate-state ...
Wonjo Jang +4 more
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G Proteins and Phototransduction
Annual Review of Physiology, 2002▪ Abstract Phototransduction is the process by which a photon of light captured by a molecule of visual pigment generates an electrical response in a photoreceptor cell. Vertebrate rod phototransduction is one of the best-studied G protein signaling pathways. In this pathway the photoreceptor-specific G protein, transducin, mediates between the visual
Vadim Y, Arshavsky +2 more
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G Protein-Coupled Receptors and G Proteins
1997G protein-coupled receptors (GPCRs) belong to a large class of membrane-spanning receptors. GPCRs function as antennae for external signals consisting of chemical ligands or photons (in the case of opsins). Once the external signal is received, it is transduced to a cytosolic G protein. Subsequently, the G protein itself becomes activated.
Paul H. J. Nederkoorn +2 more
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Current Opinion in Cell Biology, 1996
Over the past year, the thrust of work in the field of heterotrimeric G proteins has been primarily in the following areas: first, resolution of their three-dimensional structures by X-ray crystallography; second, elucidation of the effect of lipid modifications on the Galpha and Ggamma subunits; third, understanding the role of the Gbetagamma dimer in
H E, Hamm, A, Gilchrist
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Over the past year, the thrust of work in the field of heterotrimeric G proteins has been primarily in the following areas: first, resolution of their three-dimensional structures by X-ray crystallography; second, elucidation of the effect of lipid modifications on the Galpha and Ggamma subunits; third, understanding the role of the Gbetagamma dimer in
H E, Hamm, A, Gilchrist
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G Protein-Coupled Receptors and G Proteins
2000G protein-coupled receptors (GPCRs) form a large and functionally diverse superfamily of cell membrane receptors. Many signaling cascades use GPCRs to convert a large diversity of external and internal stimuli including photons, odorants, and ions as well as hormones and neurotransmitter agonists into intracellular responses.
Alfredo Ulloa-Aguirre, P. Michael Conn
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