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Science, 2002
The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G ...
Susana R, Neves +2 more
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The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G ...
Susana R, Neves +2 more
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Heterotrimeric G protein activation by G-protein-coupled receptors
Nature Reviews Molecular Cell Biology, 2008Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit.
William M, Oldham, Heidi E, Hamm
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G Proteins and G Protein-Coupled Receptors
2002Cells live in a constantly changing milieu. The structure and biochemical nature of this environment is dynamic and in order for normal cellular function to proceed in a manner appropriate for the benefit of the organism, cells must be able to access this changing information.
Michael A. Shetzline, Marc G. Caron
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G-protein-independent signaling by G-protein-coupled receptors
Trends in Neurosciences, 2000Two classes of receptors transduce neurotransmitter signals: ionotropic receptors and heptahelical metabotropic receptors. Whereas the ionotropic receptors are structurally associated with a membrane channel, a mediating mechanism is necessary to functionally link metabotropic receptors with their respective effectors.
Heuss, C, Gerber, U
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New England Journal of Medicine, 1995
The award of the 1994 Nobel Prize in Physiology or Medicine to Alfred G. Gilman and Martin Rodbell for the discovery of G (guanine nucleotide–binding) proteins and their role in cellular signal tra...
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The award of the 1994 Nobel Prize in Physiology or Medicine to Alfred G. Gilman and Martin Rodbell for the discovery of G (guanine nucleotide–binding) proteins and their role in cellular signal tra...
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G-Protein Subunit Dissociation Is not an Integral Part of G-Protein Action
ChemBioChem, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Alexander, Levitzki, Shoshana, Klein
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G-Proteins and Endothelial Responses
Blood Vessels, 2008G-proteins are transducing proteins that couple a large number of membrane-bound receptors to a variety of intracellular effector systems. Pertussis toxin ADP-ribosylates certain G-proteins causing inhibition of their function. In porcine coronary arteries, pertussis toxin inhibited the endothelium-dependent relaxations evoked by alpha-2-adrenergic or ...
Flavahan, NA, Vanhoutte, PM
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Nature Reviews Molecular Cell Biology, 2005
The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and
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The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and
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G Protein‐Coupled Receptors and the G Protein Family
Comprehensive Physiology, 1997Abstract The sections in this article are: Structure of G Protein‐Coupled Receptors General Features Ligand‐Binding Domain G ...
Alfredo Ulloa‐Aguirre, P. Michael Conn
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G Proteins In Signal Transduction
Annual Review of Pharmacology and Toxicology, 1990The last five years have seen major advances in our understanding of the central and generalized role of G-proteins as transducers of receptor signals into effector responses as outlined in Scheme 1. Signal-transducing G pro teins, in contrast to other GTP-binding proteins, are heterotrimers formed of one GTP-binding (and hydrolyzing) a subunit, one ...
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