Results 31 to 40 of about 133,403 (291)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Ka-band GaAs pHEMT Wideband Power Amplifier MMICs

Известия высших учебных заведений России: Радиоэлектроника
Introduction. Ka-band power amplifier MMICs are essential components of many electronic systems. Their application area covers radar, 5G communication, and test equipment.
Alexander S. Efimov, Artem M. Emelianov, Evgeniya A. Krivonogova, Sergey D. Zinkin, Alexander V. Grusha   +4 more
doaj   +1 more source

Structural Features and Photoelectric Properties of Si-Doped GaAs under Gamma Irradiation

Nanomaterials, 2020
GaAs has been demonstrated to be a promising material for manufacturing semiconductor light-emitting devices and integrated circuits. It has been widely used in the field of aerospace, due to its high electron mobility and wide band gap.
Ye Shen, Xuan Fang, Xiang Ding, Haiyan Xiao, Xia Xiang, Guixia Yang, Ming Jiang, Xiaotao Zu, Liang Qiao   +8 more
doaj   +1 more source

Calculate the energy levels of vanadium V2+-grafted semiconductor GaAs using the theoretical orthogonal compliant model [PDF]

مجلة التربية والعلم, 2006
To evaluate the energy level for Vanadium ion in GaAs: V2+ the ground term has determined (4F). Using the concepts of isomorphism on orbital states for the ground term of GaAs: V2+ where the states are described by fictitious orbits of L'=0, T=1/2 & L'=1,
Adnan Al-Shekh, Ibtisam Abdullah
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Comparative Transcriptome Profiling Reveals Defense-Related Genes Against Ralstonia solanacearum Infection in Tobacco

Frontiers in Plant Science, 2021
Bacterial wilt (BW) caused by Ralstonia solanacearum (R. solanacearum), is a vascular disease affecting diverse solanaceous crops and causing tremendous damage to crop production.
Xiaoying Pan, Junbiao Chen, Aiguo Yang, Qinghua Yuan, Weicai Zhao, Tingyu Xu, Bowen Chen, Min Ren, Ruimei Geng, Zhaohui Zong, Zhuwen Ma, Zhenrui Huang, Zhenchen Zhang   +12 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evolutionary analysis of the Dof family in plants and identification of its members in tobacco

Frontiers in Plant Science
DNA-binding with One Finger (Dof) transcription factors are plant-specific regulators involved in diverse biological processes, including growth, development, and stress responses.
Bolun Zhi, Bolun Zhi, Hao Chen, Xuebo Wang, Chuanliang Liu, Jiqin Li, Zhuwen Ma, Weicai Zhao, Zhenrui Huang, Xiaoying Pan   +9 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Integrated transcriptomics and metabolomics provides insights into the Nicotiana tabacum response to heat stress

Frontiers in Plant Science
Heat stress is a prevalent factor that significantly damages crops, especially with the ongoing global warming and increasing frequency of extreme weather events.
Hao Chen, Shaoxin Qiu, Shaoxin Qiu, Yuanping Chen, Jiqin Li, Tingyu Xu, Pingzhan Zhong, Xiuhong Shao, Shihuan Xu, Zhuwen Ma, Zhenrui Huang, Xiaoying Pan   +11 more
doaj   +1 more source