Results 1 to 10 of about 258,602 (310)

Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in Sprague-Dawley Rats by Altering Gut Microbiota and Striatum Metabolism

Neuropsychiatric Disease and Treatment
Ying Xu,1,2 Li-Na Li,1,2,* Xiang-Jun He,1,2 Shuang Wang,2 Xincheng Li,2 Hao Feng,2 Hui-Feng Zhang,1 Li Song,2 Hai-Shui Shi,2– 4,* Xiao-Yu Tian1,* 1The Department of Pediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang ...
Xu Y, Li LN, He XJ, Wang S, Li X, Feng H, Zhang HF, Song L, Shi HS, Tian XY   +9 more
doaj   +2 more sources

Antinociceptive and anti-inflammatory effect of a standardized fraction of Oenothera rosea L'Hér. ex Aiton and its possible mechanism of action in mice [PDF]

Avicenna Journal of Phytomedicine, 2022
Objective: This study was conducted to investigate the antinociceptive and anti-inflammatory effect of ethyl acetate fraction of Oenothera rosea (EAOr) and the mechanism involved, in mice.Materials and Methods: The antinociceptive activity was tested ...
Rodrigo Vargas-Ruiz, Jose Eduardo Roa-Coria, Arturo Mora-Olivo, Alejandro Zamilpa, Maribel Lucila Herrera-Ruiz, Rosa Issel Acosta-Gonzalez, Rosa Mariana Montiel-Ruiz   +6 more
doaj   +1 more source

Study on the Effect of Ziziphi spinosae Semen Poria cocos Powder and Soybean Peptide Powder on Improving Sleep in Insomnia Model Mice

Shipin gongye ke-ji, 2023
Objective: To study the sleep-improving effect of Ziziphi spinosae Semen Poria cocos powder and soybean peptide powder on insomnia model mice induced by p-chlorophenylalanine (PCPA). Methods: One hundred eighty SPF male BALB/c mice were purchased. First,
Rong WEI, Zhen WANG, Huaiping LI, Yu GUO, Jian ZHAO   +4 more
doaj   +1 more source

Effect of berrycactus fruit (Myrtillocactus geometrizans) on glutamate, glutamine, and GABA levels in the frontal cortex of rats fed with a high-fat diet

Open Life Sciences, 2023
In addition to the known metabolic alterations, obesity has consequences at the brain level, driving imbalance in neurotransmitters such as glutamate (Glu), glutamine (Gln), and gamma-aminobutyric acid (GABA).
Sandoval-Salazar Cuauhtémoc, Jiménez-García Sandra Neli, Beltrán-Campos Vicente, Vera-Becerra Luz Elvia, Núñez-Colín Carlos Alberto   +4 more
doaj   +1 more source

A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice

Frontiers in Immunology, 2022
Gamma-aminobutyric acid (GABA) and GABA-receptors (GABA-Rs) form a major neurotransmitter system in the brain. GABA-Rs are also expressed by 1) cells of the innate and adaptive immune system and act to inhibit their inflammatory activities, and 2) lung ...
Jide Tian, Barbara J. Dillion, Jill Henley, Lucio Comai, Daniel L. Kaufman   +4 more
doaj   +1 more source

Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions

Chemical Reviews, 2018
Richard B Silverman
exaly   +3 more sources

Psychobiotics – Probiotics that Improve Mood

Harčova Nauka ì Tehnologìâ, 2021
The human intestinal microbiome includes all microorganisms inhabiting the intestinal tract. One study showed that mice raised in a sterile environment exhibited excessive physiological responses to stress compared to normal control.
L. Kapreliants, E Zhuk
doaj   +1 more source

Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management

Arhiv za Higijenu Rada i Toksikologiju, 2020
Gamma-hydroxybutyrate (GHB) is a central nervous system depressant primarily used as a recreational drug of abuse, but also for the treatment of narcolepsy with cataplexy in adult patients and as an adjuvant for control of alcohol withdrawal syndrome ...
Marinelli Enrico, Beck Renata, Malvasi Antonio, Faro Alfredo Fabrizio Lo, Zaami Simona   +4 more
doaj   +1 more source

Understanding complexities of synaptic transmission in medically intractable seizures: A paradigm of epilepsy research

Indian Journal of Neurosurgery, 2013
Investigating the changes associated with the development of epileptic state in humans is complex and requires a multidisciplinary approach. Understanding the intricacies of medically intractable epilepsy still remains a challenge for neurosurgeons ...
Jyotirmoy Banerjee, Manjari Tripathi, P. Sarat Chandra   +2 more
doaj   +1 more source

Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice

Journal of Integrative Neuroscience, 2023
Background: Mefenamic acid (MFA), a common analgesic, causes central nervous system (CNS) toxicity at high doses with a proposed activity on the Gamma-aminobutyric acid (GABA) system.
Qais Jarrar, Rami Ayoub, Yazun Jarrar, Hadeel Aburass, Khang Wen Goh, Chrismawan Ardianto, Long Chiau Ming, Said Moshawih, Hussain Alfaqih   +8 more
doaj   +1 more source