Results 181 to 190 of about 171,723 (359)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors [PDF]

, 1990
K Varga, George Kunos
openalex   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

GABA_B receptor modulation of the release of substance P from capsaicin‐sensitive neurones in the rat trachea in vitro [PDF]

, 1991
Nick Ray, Alan J. Jones, P. Keen
openalex   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Postnatal development of the benzodiazepine and GABA receptors in the rat spinal cord.

, 1983
Kenichi Saito, Masayoshi Goto, Hideomi Fukuda   +2 more
openalex   +1 more source

Effects of GABA and various allosteric ligands on TBPS binding to cloned rat GABA_A receptor subtypes [PDF]

, 1994
Wha Bin Im, Jeffrey F. Pregenzer, D R Thomsen   +2 more
openalex   +1 more source

Efficacy and tolerability of fenfluramine with concomitant potassium bromide in patients with Dravet syndrome

Epilepsia Open, EarlyView.
Abstract Objective To assess the efficacy and tolerability of fenfluramine (FFA) with concomitant potassium bromide (BR) in patients with Dravet syndrome (DS). Methods This multicenter retrospective study, conducted within the German compassionate use program, analyzed BR doses and serum levels before and after FFA initiation, adverse events (AEs ...
Milka Pringsheim, Gerhard Kluger, Adam Strzelczyk, Susanne Schubert‐Bast, Thomas Mayer, Benjamin Glauche, Hiltrud Muhle, Michael Alber, Hartwig Spors, Tilmann Polster, Regina Trollmann, Gerhard Kurlemann, Markus Berndt, Kerstin A. Klotz   +13 more
wiley   +1 more source

Structure and function of .GAMMA.-aminobutyric acid (GABA) receptor: Current state and prospectives.

, 1989
Kinya Kuriyama, Masaaki Hirouchi
openalex   +2 more sources

Molecular biology of GABA _A receptors [PDF]

, 1990
Richard W. Olsen, Allan J. Tobin
openalex   +1 more source