Results 21 to 30 of about 258,602 (310)

Structure of a human synaptic GABA-A receptor

open access: yesNature, 2018
Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA receptor).
Shaotong Zhu   +5 more
semanticscholar   +1 more source

Investigation of the Effect of Anakinra on Pentylenetetrazole-Induced Epileptic Seizures in Mice

open access: yesAhi Evran Medical Journal, 2021
Purpose: Disruption of the balance between gamma aminobutyric acid (GABA) and glutamate in the brain is one of the important factors contributing to seizure formation and epileptogenesis.
Ahmet Kemal FİLİZ   +1 more
doaj   +1 more source

Gamma-aminobutyric acid (GABA) alleviates salt damage in tomato by modulating Na+ uptake, the GAD gene, amino acid synthesis and reactive oxygen species metabolism

open access: yesBMC Plant Biology, 2020
Background Salt stress is a serious abiotic stress that caused crop growth inhibition and yield decline. Previous studies have reported on the the synthesis of gamma-aminobutyric acid (GABA) and its relationship with plant resistance under various ...
Xiaolei Wu   +6 more
semanticscholar   +1 more source

Mesencephalic GABA neuronal development: no more on the other side of oblivion

open access: yesBiomolecular Concepts, 2014
Midbrain GABA neurons, endowed with multiple morphological, physiological and molecular characteristics as well as projection patterns are key players interacting with diverse regions of the brain and capable of modulating several aspects of behavior ...
Li Suyan, Joshee Sampada, Vasudevan Anju
doaj   +1 more source

Targeted knockout of GABA-A receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae

open access: yesDisease Models & Mechanisms, 2019
Epilepsy is a common primary neurological disorder characterized by the chronic tendency of a patient to experience epileptic seizures, which are abnormal body movements or cognitive states that result from excessive, hypersynchronous brain activity ...
Meijiang Liao   +7 more
doaj   +1 more source

Effectiveness of germinated brown rice on metabolic syndrome: A randomized control trial in Vietnam

open access: yesAIMS Public Health, 2020
To treating Metabolic Syndrome (MetS) in the human body by using cooked pre- germinated brown rice (PGBR), a randomized control trial was done in Vietnam. 80 subjects (65.1 ± 3.81 years old) separated into two groups in pairs were assigned a daily intake
Truong Tuyet Mai   +2 more
doaj   +1 more source

L-655,708 does not prevent isoflurane-induced memory deficits in old mice

open access: yesTranslational Neuroscience, 2019
General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents for the prevention or treatment of POCD are urgently needed.
Gao Teng   +6 more
doaj   +1 more source

Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus

open access: yesPharmaceuticals, 2019
Lurasidone is an atypical mood-stabilizing antipsychotic agent with unique receptor-binding profile, including 5-HT7 receptor (5-HT7R) antagonism. Effects of 5-HT7R antagonism on transmitter systems of schizophrenia and mood disorders, however, have not ...
Motohiro Okada   +4 more
doaj   +1 more source

Phenotype Expression Variability in Children with GABRB3 Heterozygous Mutations

open access: yesOman Medical Journal, 2021
GABRB3 gene is a recently identified gene located in 15q12 chromosome and encodes for gamma-aminobutyric acid (GABA) receptor subunit beta-3 protein, which is linked to the GABAA receptor.
Abdulhafeez M. Khair, Alana E. Salvucci
doaj   +1 more source

Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice

open access: yesJournal of Integrative Neuroscience, 2023
Background: Astrocytes are essential for synaptic transmission, and their dysfunction can result in neuropsychiatric disorders such as anxiety and depression.
Zijun Meng   +11 more
doaj   +1 more source

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