Results 21 to 30 of about 245,202 (346)
GABA as a rising gliotransmitter [PDF]
Frontiers in Neural Circuits, 2014 Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors in neighboring neurons.
C. Justin Lee, Bo-Eun Yoon
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GABA Modulating Bacteria of the Human Gut Microbiota
Nature Microbiology, 2018 The gut microbiota affects many important host functions, including the immune response and the nervous system1. However, while substantial progress has been made in growing diverse microorganisms of the microbiota2, 23–65% of species residing in the ...
Philip Strandwitz +18 more
semanticscholar +1 more source
L-655,708 does not prevent isoflurane-induced memory deficits in old mice
Translational Neuroscience, 2019 General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents for the prevention or treatment of POCD are urgently needed.
Gao Teng +6 more
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Pharmaceuticals, 2019 Lurasidone is an atypical mood-stabilizing antipsychotic agent with unique receptor-binding profile, including 5-HT7 receptor (5-HT7R) antagonism. Effects of 5-HT7R antagonism on transmitter systems of schizophrenia and mood disorders, however, have not ...
Motohiro Okada +4 more
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Structure of a human synaptic GABA-A receptor
Nature, 2018 Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABAA receptor).
Shaotong Zhu +5 more
semanticscholar +1 more source
Glutamate Decarboxylase from Lactic Acid Bacteria—A Key Enzyme in GABA Synthesis
Microorganisms, 2020 Glutamate decarboxylase (l-glutamate-1-carboxylase, GAD; EC 4.1.1.15) is a pyridoxal-5’-phosphate-dependent enzyme that catalyzes the irreversible α-decarboxylation of l-glutamic acid to γ-aminobutyric acid (GABA) and CO2.
Ida Bagus Agung Yogeswara +2 more
semanticscholar +1 more source
Disease Models & Mechanisms, 2019 Epilepsy is a common primary neurological disorder characterized by the chronic tendency of a patient to experience epileptic seizures, which are abnormal body movements or cognitive states that result from excessive, hypersynchronous brain activity ...
Meijiang Liao +7 more
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Investigation of the Effect of Anakinra on Pentylenetetrazole-Induced Epileptic Seizures in Mice
Ahi Evran Medical Journal, 2021 Purpose: Disruption of the balance between gamma aminobutyric acid (GABA) and glutamate in the brain is one of the important factors contributing to seizure formation and epileptogenesis.
Ahmet Kemal FİLİZ +1 more
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GABA Generates Excitement [PDF]
Neuron, 2003 In the CNS, gamma-aminobutyric acid (GABA) acts as an inhibitory transmitter via ligand-gated GABA(A) receptor channels and G protein-coupled GABA(B) receptors. Both of these receptor types mediate inhibitory postsynaptic transmission throughout the nervous system. For GABA(A) receptors, this inhibitory action is associated with a hyperpolarization due
Roger A. Nicoll, Valentin Stein
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BMC Plant Biology, 2020 Background Salt stress is a serious abiotic stress that caused crop growth inhibition and yield decline. Previous studies have reported on the the synthesis of gamma-aminobutyric acid (GABA) and its relationship with plant resistance under various ...
Xiaolei Wu +6 more
semanticscholar +1 more source