Results 121 to 130 of about 47,360 (258)

Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice

FASEB BioAdvances, Volume 8, Issue 2, February 2026.
Oral supplementation of aging mice with a nuclear fraction extract of bovine thymus (TNF) leads to significant increases in GAD65, GAD67, and β2/β3 subunits of the GABAA receptor, more so with high dose (HD) TNF treatment compared to low dose (LD) and control condition.
Abdeslem El‐Idrissi, Natalia Surzenko, Bassem F. El‐Khodor   +2 more
wiley   +1 more source

GABAA Receptor Assembly [PDF]

Journal of Biological Chemistry, 2000
Thomas Klausberger, Karoline Fuchs, Bernd Mayer, Noosha Ehya, Werner Sieghart   +4 more
openaire   +1 more source

Zuranolone, a positive allosteric modulator of the GABAA receptor and a neuroactive steroid: hypothesized mechanism of action in depression

, 2023
Jason Payne, Jodi L. Pawluski, Astrid Althaus, Shirley J. Gee, Tomás Ripoll‐Vera, Nicholas D’Alberto, Simon Kyaga, M. Kotecha, Mark H. Pollack, Roger S. McIntyre, Stephen M. Stahl   +10 more
openalex   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

Erratum: AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. [PDF]

Front Mol Neurosci, 2023
Frontiers Production Office.
europepmc   +1 more source

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. [PDF]

Front Mol Neurosci, 2023
Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ.   +9 more
europepmc   +1 more source

A propofol binding site on mammalian GABAA receptors identified by photolabeling

, 2013
Grace M S Yip, Zi-Wei Chen, Christopher J. Edge, Edward H. Smith, Robert Dickinson, Erhard Hohenester, R. Reid Townsend, Karoline Fuchs, Werner Sieghart, Alex S. Evers, Nicholas P. Franks   +10 more
openalex   +2 more sources

EXTH-99. SYSTEMIC AND BRAIN PHARMACOKINETICS OF A GABAA RECEPTOR AGONIST, AMLAL-101, AS AN INVESTIGATIONAL THERAPEUTIC FOR THE TREATMENT OF PRIMARY AND METASTATIC BRAIN CANCERS [PDF]

, 2022
Aniruddha S. Karve, Taukir Ahmed, Janki Desai, Debanjan Bhattacharya, Donatien Kamdem Toukam, Sidharth N. Gadgil, Merissa Pemberton, David R. Plas, Gary A. Gudelsky, Larry Sallans, James M. Cook, Pankaj B. Desai, Daniel Pomeranz Krummel, Soma Sengupta   +13 more
openalex   +1 more source