Results 21 to 30 of about 47,360 (258)

Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system

Frontiers in Psychiatry, 2023
AimTo explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder.MethodsIn this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia ...
Ting Xiang, Ting Xiang, Jiwu Liao, Yixian Cai, Yixian Cai, Mei Fan, Mei Fan, Congrui Li, Xiaotao Zhang, Hongyao Li, Yushan Chen, Jiyang Pan, Jiyang Pan   +12 more
doaj   +1 more source

Lamina-specific changes in hippocampal GABAA/cBZR and mossy fibre sprouting during and following amygdala kindling in the rat

Neurobiology of Disease, 2009
Alterations in hippocampal GABAA/central benzodiazepine receptor (GABAA/cBZR) expression and mossy fibre sprouting (MFS) may have aetiological significance in temporal lobe epileptogenesis. Their relationship with each other is also unknown. We utilised [
David S.H. Liu, Terence J. O'Brien, David A. Williams, Rodney J. Hicks, Damian E. Myers   +4 more
doaj   +1 more source

The seizure‐inducing plastic explosive RDX inhibits the α1β2γ2 GABAA receptor

Annals of Clinical and Translational Neurology, 2022
Objective Royal demolition explosive (RDX) can induce seizures in wildlife and humans following release into the environment or after voluntary consumption.
Brandon Pressly, Ruth D. Lee, Vikrant Singh, Isaac N. Pessah, Heike Wulff   +4 more
doaj   +1 more source

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Cell & Bioscience, 2022
Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy.
Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch, R. Luke Wiseman, Jeffery W. Kelly, Angelo Keramidas, Ting-Wei Mu   +9 more
doaj   +1 more source

Two Distinct Populations of α1α6-Containing GABAA-Receptors in Rat Cerebellum

Frontiers in Synaptic Neuroscience, 2020
GABAA receptors are pentameric GABA-gated chloride channels. The existence of 19 different subunits (six α, three β, three γ, δ, ε, θ, π, and three ρ) in mammalian systems gives rise to an enormous theoretical diversity of GABAA receptor subtypes with ...
Petra Scholze, Michael Pökl, Severin Längle, Friederike Steudle, Jure Fabjan, Margot Ernst   +5 more
doaj   +1 more source

Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.

PLoS ONE, 2015
A developmental "switch" in chloride transporters occurs in most neurons resulting in GABAA mediated hyperpolarization in the adult. However, several neuronal cell subtypes maintain primarily depolarizing responses to GABAA receptor activation.
Carol Taylor-Burds, Paul Cheng, Susan Wray   +2 more
doaj   +1 more source

Peripheral-Type Benzodiazepine Receptor Antagonist Is Effective in Relieving Neuropathic Pain in Mice

Journal of Pharmacological Sciences, 2009
.: cDNA microarray analysis showed the expression of peripheral-type benzodiazepine receptor (PBR) mRNA is slightly enhanced in the spinal cord of mice with spinal nerve injury (SNL) as compared with sham-operated mice.
Daisuke Kondo, Hironao Saegusa, Ritsuko Yabe, Ichiro Takasaki, Takashi Kurihara, Shuqin Zong, Tsutomu Tanabe   +6 more
doaj   +1 more source

Neurosteroid involvement in threatened preterm labour

Endocrinology, Diabetes & Metabolism, 2021
Introduction The neurosteroid allopregnanolone modulates oxytocin expression in the brain, and its effects arise from its action on the GABAA receptor. Whether neurosteroid levels and the function of the GABAA receptor are involved in the risk of preterm
Sahruh Turkmen, Torbjörn Bäckström, Yvonne Kangas Flodin, Marie Bixo   +3 more
doaj   +1 more source

Cancer Stem Cells are Depolarized Relative to Normal Stem Cells Derived from Human Livers

Annals of Hepatology, 2017
Introduction and aim. The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC).
Wendy Bautista, Jeremy Lipschitz, Andrew McKay, Gerald Y. Minuk   +3 more
doaj   +1 more source

Three epilepsy-associated GABRG2 missense mutations at the γ+/β− interface disrupt GABAA receptor assembly and trafficking by similar mechanisms but to different extents

Neurobiology of Disease, 2014
We compared the effects of three missense mutations in the GABAA receptor γ2 subunit on GABAA receptor assembly, trafficking and function in HEK293T cells cotransfected with α1, β2, and wildtype or mutant γ2 subunits.
Xuan Huang, Ciria C. Hernandez, Ningning Hu, Robert L. Macdonald   +3 more
doaj   +1 more source