Cell & Bioscience, 2022 Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy.
Meng Wang +9 more
doaj +1 more source
Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core +2 more sources
Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]
, 2020 OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A +3 more
core +2 more sources
PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway
Cellular Physiology and Biochemistry, 2015 Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
Guang Yang +3 more
doaj +1 more source
Frontiers in Psychiatry, 2023 Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress ...
Qian Gao +26 more
doaj +1 more source
Effects of insecticidal ketones present in mint plants on GABA A receptor from mammalian neurons [PDF]
, 2017 The genus Mentha, an important member of the Lamiaceae family, is represented by many species commonly known as mint. The insecticidal activity of Mentha oil and its main components has been tested and established against various insects/pests.
Delgado Marín, Leticia Ester +2 more
core +2 more sources
The seizure‐inducing plastic explosive RDX inhibits the α1β2γ2 GABAA receptor
Annals of Clinical and Translational Neurology, 2022 Objective Royal demolition explosive (RDX) can induce seizures in wildlife and humans following release into the environment or after voluntary consumption.
Brandon Pressly +4 more
doaj +1 more source
Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes [PDF]
, 2015 BACKGROUND: GABAA receptor subunit composition has a profound effect on the receptor's physiological and pharmacological properties. The receptor β subunit is widely recognised for its importance in receptor assembly, trafficking and post-translational ...
Smart, TG, Villumsen, IS, Wellendorph, P
core +1 more source
Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system
Frontiers in Psychiatry, 2023 AimTo explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder.MethodsIn this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia ...
Ting Xiang +12 more
doaj +1 more source
Allosteric modulation of retinal GABA receptors by ascorbic acid [PDF]
, 2011 Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells.
Aguayo, Luis G. +5 more
core +1 more source