Results 21 to 30 of about 2,290,618 (347)
Pharmacological Reviews, 2018 GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive steroids, anesthetics, and convulsants. GABAA receptors are composed
W. Sieghart, M. Savić
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PKCε and Allopregnanolone: functional cross-talk at the GABAA receptor level
Frontiers in Cellular Neuroscience, 2015 Changes in GABAergic inhibition occur during physiological processes, during response to drugs and in various pathologies. These changes can be achieved through direct allosteric modifications at the γ-aminobutyric (GABA) type A (GABAA) receptor protein ...
Giulia ePuja +3 more
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Conformational Dynamics in the GABAA Receptor [PDF]
Biophysical Journal, 2015 GABAA receptors are members of the cys-loop family of ligand-gated ion channels and are pentameric ion channels that are closed in the absence of ligand, but upon ligand-binding, open to allow anions to pass through a central pore. The sustained application of agonist however leads to the receptor entering a desensitized state whereby the agonist is ...
Philip C. Biggin, Rilei Yu
openaire +2 more sources
Journal of Neuroscience, 1992 The expression patterns of 13 GABAA receptor subunit encoding genes (alpha 1-alpha 6, beta 1-beta 3, gamma 1-gamma 3, delta) were determined in adult rat brain by in situ hybridization.
W. Wisden +3 more
semanticscholar +1 more source
Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source
Cell & Bioscience, 2022 Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy.
Meng Wang +9 more
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Frontiers in Psychiatry, 2023 Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress ...
Qian Gao +26 more
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Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions
Science, 2019 Fine control of brain GABAA receptors GABAA (γ-aminobutyric acid type A) receptors are ligand-gated anion channels that mediate fast inhibitory transmission in the mammalian brain. Han et al.
Wenyan Han +15 more
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International Journal of Cancer, Volume 152, Issue 5, Page 998-1012, 1 March 2023., 2023 What's new? The spatial distribution of glioma is nonrandom. However, whether pathological grade influences glioma distribution across the brain remains unclear. Here, the authors built a population‐based frequency map for 396 patients with glioblastoma multiforme and 190 patients with lower‐grade glioma, revealing their distinct topographic ...
Hongbo Bao +10 more
wiley +1 more source
PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway
Cellular Physiology and Biochemistry, 2015 Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons.
Guang Yang +3 more
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