Results 51 to 60 of about 759,534 (341)
GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus
Journal of Neural Transplantation and Plasticity, 2012 In the nervous system, there are a wide variety of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics.
Kei Hori, M. Hoshino
semanticscholar +1 more source
The enigmatic function of chandelier cells
Frontiers in Neuroscience, 2010 Chandelier (or axo-axonic) cells are one of the most distinctive GABAergic interneurons in the brain. Their exquisite target specificity for the axon initial segment of pyramidal neurons, together with their GABAergic nature, long suggested the ...
Alan R Woodruff +2 more
doaj +1 more source
GABAergic mechanism of propofol toxicity in immature neurons [PDF]
Journal of Neurosurgical Anesthesiology, 2006 Certain anesthetics exhibit neurotoxicity in the brains of immature but not mature animals. Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, is excitatory on immature neurons via its action at the GABAA receptor, due to a reversed transmembrane chloride gradient.
Sibel, Kahraman +3 more
openaire +2 more sources
PLoS ONE, 2011 Idiopathic generalized epilepsy (IGE) syndromes represent about 30% of all epilepsies. They have strong, but elusive, genetic components and sex-specific seizure expression.
L. Velíšek +7 more
semanticscholar +1 more source
The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen +5 more
wiley +1 more source
Journal of Neuroscience, 2011 An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D2 receptors, which are the main target of antipsychotics, modulate ...
B. R. Souza +2 more
semanticscholar +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Integrins Have Cell-Type-Specific Roles in the Development of Motor Neuron Connectivity
Journal of Developmental Biology, 2019 Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in ...
Devyn Oliver +7 more
doaj +1 more source
Deletion of FGF9 in GABAergic neurons causes epilepsy
Cell Death and Disease, 2021 Fibroblast growth factor 9 (FGF9) has long been assumed to modulate multiple biological processes, yet very little is known about the impact of FGF9 on neurodevelopment.
Moran Guo +16 more
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Frontiers in Systems Neuroscience, 2011 Substantia nigra pars reticulata (SNr) GABAergic neurons are key output neurons of the basal ganglia. Given the role of these neurons in motor control, it is important to understand factors that regulate their firing rate and pattern.
Christian R. Lee, P. Witkovsky, M. Rice
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