Results 61 to 70 of about 759,534 (341)
GABAergic neuronal IL-4R mediates T cell effect on memory
Neuron, 2021 Mechanisms governing how immune cells and their derived molecules impact homeostatic brain function are still poorly understood. Here, we elucidate neuronal mechanisms underlying effects of T cells on synaptic function and episodic memory.
Jasmin Herz +15 more
semanticscholar +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
PLoS Computational Biology, 2021 Loss of function mutations of SCN1A, the gene coding for the voltage-gated sodium channel NaV1.1, cause different types of epilepsy, whereas gain of function mutations cause sporadic and familial hemiplegic migraine type 3 (FHM-3).
Louisiane Lemaire +5 more
doaj +1 more source
Neurobiology of Stress, 2022 Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji +6 more
doaj +1 more source
Kv4 channel expression and kinetics in GABAergic and non-GABAergic rNST neurons
Journal of Neurophysiology, 2020 Here, we demonstrate that the transient outward K+ current IA occurs in both GABAergic and non-GABAergic neurons via Kv4.3 channels in the rostral (gustatory) solitary nucleus. Although found in both cell types, IA is more prevalent in non-GABAergic cells; a larger conductance at more negative potentials leads to a greater impact on spike initiation ...
Z, Chen +7 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang +9 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2018 Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the ...
Boldizsár Czéh +15 more
doaj +1 more source
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
Communications Biology, 2023 XBP1s is a key effector of the unfolded protein response. Neuron-specific overexpression of Xbp1s in the brain leads to impaired GABAergic signaling and recurrent spontaneous seizures in mice.
Zhuoran Wang +17 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Neurogenesis persists in the mammalian subventricular zone after birth, producing various populations of olfactory bulb (OB) interneurons, including GABAergic and mixed dopaminergic/GABAergic (DA) neurons for the glomerular layer. While olfactory sensory
Alexandra Angelova +4 more
doaj +1 more source