Results 71 to 80 of about 759,534 (341)
Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation
Brain : a journal of neurology, 2021 Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating focally targeted strategies such as surgical resection or the modulation of the activity of specific hippocampal neuronal populations through genetic or optogenetic ...
Katerina Hristova +7 more
semanticscholar +1 more source
GABAergic neurons in the mammalian intestine.
Folia Pharmacologica Japonica, 1985 Most of the criteria for identification of a neurotransmitter were satisfied for gamma-aminobutyric acid (GABA) in the mammalian intestine. GABA and its synthesizing enzyme, glutamic acid decarboxylase, and the neurons which specifically accumulate GABA were demonstrated to localize in Auerbach's plexus of the intestine.
openaire +3 more sources
Advanced Science, EarlyView.Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti +11 more
wiley +1 more source
Differential pH Dynamics in Synaptic Vesicles From Intact Glutamatergic and GABAergic Synapses
Frontiers in Synaptic Neuroscience, 2018 Synaptic transmission requires the presynaptic release of neurotransmitter from synaptic vesicles (SVs) onto the postsynaptic neuron. Vesicular neurotransmitter transporter proteins, which use a V-ATPase-generated proton gradient, play a crucial role in ...
Melissa A. Herman +2 more
doaj +1 more source
Frontiers in Neural Circuits, 2020 A unique feature of the olfactory system is the continuous generation and integration of new neurons throughout adulthood. Adult-born neuron survival and integration is dependent on activity and sensory experience, which is largely mediated by early ...
Elizabeth Hanson +5 more
doaj +1 more source
Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development. [PDF]
PLoS ONE, 2013 Central nervous system GABAergic and glycinergic synaptic activity switches from postsynaptic excitation to inhibition during the stage when motor neuron numbers are being reduced, and when synaptic connections are being established onto and by motor ...
Matthew J Fogarty +5 more
doaj +1 more source
Advanced Science, EarlyView.Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li +13 more
wiley +1 more source
GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression [PDF]
, 2022 Ya-Nan Zhao +7 more
openalex +1 more source
Necdin Promotes GABAergic Neuron Differentiation in Cooperation with Dlx Homeodomain Proteins
Journal of Neuroscience, 2006 Necdin, a member of the MAGE (melanoma antigen) protein family, is expressed predominantly in terminally differentiated neurons. The necdin gene NDN is maternally imprinted and expressed only from the paternal allele, the deficiency of which is ...
Takaaki Kuwajima +2 more
semanticscholar +1 more source
Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors
Advanced Science, EarlyView.Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon +10 more
wiley +1 more source