Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source
Comparison of gabapentin with estrogen for treatment of hot flashes in post-menopausal women
Objective: Various non-hormonal agents have been used for the treatment of hot flashes in women with menopause. Some studies have reported that gabapentin appears to be an effective and well-tolerated treatment modality.
Zahra Allameh +2 more
doaj +1 more source
Comparative performance of catalytic Fenton oxidation with zero-valent iron (Fe(0)) in comparison with ferrous sulphate for the removal of micropollutants [PDF]
This research aims to depict the comparative performance of micropollutants’ removal by FeSO4- and zero-valent iron (Fe(0))-catalytic Fenton oxidation and to explore the possibilities of minimising the sludge production from the process.
Goswami, Anuradha, Jiang, Jia-Qian
core +2 more sources
An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha +13 more
wiley +1 more source
Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States
Abstract Objective National prescribing trends for antiseizure medication (ASM) in children with epilepsy over the past decade are unclear. Despite the 2021 SANAD II trials supporting lamotrigine and valproate for focal and generalized epilepsies, respectively, it is unknown if their use increased.
Adam P. Ostendorf +6 more
wiley +1 more source
Designing the ideal perioperative pain management plan starts with multimodal analgesia. [PDF]
Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects ...
Mariano, Edward R., Schwenk, Eric S.
core +1 more source
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]
Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke +3 more
core +1 more source
Real-World Treatment of Post-herpetic Neuralgia with Gabapentin or Pregabalin [PDF]
BACKGROUND AND OBJECTIVES: There are limited data examining the real-world use of gabapentin and pregabalin for the treatment of post-herpetic neuralgia (PHN).
Laura Becker +3 more
core +1 more source
Things We Do for No Reason™: Prescribing gabapentinoids for pain
Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel +4 more
wiley +1 more source
BACKGROUND AND OBJECTIVES: Gabapentin is an anticonvulsant drug which also possesses antinociceptive effect in wide spectrum kind of pain, like neuropathic pain. However its effectiveness on visceral pain is not elucidated yet.
M Meimandi +3 more
doaj

