Results 41 to 50 of about 6,786 (213)
International Journal of Population Data Science, 2022 Background As dispensings for benzodiazepines and gabapentinoids have increased in recent years, risk of increased mortality has been identified, particularly when used with opioids. There is limited research examining use of these medicines among people
Chrianna Bharat +6 more
doaj +1 more source
, 2023 International audienceAims : Gabapentin and pregabalin bind to α2‐δ subunit of voltage‐gated calcium channels (Cav). Other drugs targeting Cav include cardiovascular calcium channel blockers (CCBs) and anticonvulsants (levetiracetam, ethosuximide and ...
Giraudeau, Bruno +9 more
core +1 more source
The Anti-Allodynic Gabapentinoids: Myths, Paradoxes, and Acute Effects [PDF]
, 2017 The gabapentinoids (pregabalin and gabapentin) are first line treatments for neuropathic pain. They exert their actions by binding to the α2δ accessory subunits of voltage-gated Ca2+ channels.
Smith, PA, Alles, SRA
core +1 more source
Gabapentin as an add‐on analgesic to morphine in paediatric patients with chronic pain
British Journal of Clinical Pharmacology, EarlyView.Aims Off‐label use of gabapentin for the treatment of chronic pain in children has increased over the last decade, with multiple clinical trials evaluating its role pain management and potential opioid‐sparing effects. To date, however, these studies appear to rely on empirical evidence without further consideration of pharmacokinetic‐pharmacodynamic ...
Paul Healy +15 more
wiley +1 more source
Translational development of crisugabalin for neuropathic pain
British Journal of Clinical Pharmacology, EarlyView.Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João +5 more
wiley +1 more source
Diabetic painful polyneuropathy treatment [PDF]
Serbian Journal of Anesthesia and Intensive Therapy, 2017 Diabetic peripheral neuropathies (DPN) are a heterogeneous group of disorders caused by neuronal dysfunction in patients with diabetes. Among all acquired polyneuropathy, diabetic polyneuropathy is the most common, and therefore the most important one ...
Terzić Branka
doaj +1 more source
Benzodiazepines use in primary care England: Prescribing patterns and adverse consequences
British Journal of Clinical Pharmacology, EarlyView.Aims Benzodiazepines (BZDs) are commonly prescribed for anxiety and insomnia but carry risks such as dependence, adverse drug reactions (ADRs) and mortality. Despite deprescribing efforts, the influence of recent prescribing trends, COVID‐19 and adverse outcomes on prescribing patterns in England remains uncertain.
Alvina Chaudhry +3 more
wiley +1 more source
Assessing kidney function for drug dosing in critical illness
British Journal of Clinical Pharmacology, EarlyView.Kidney‐function assessment supports drug dosing in critical illness but does not directly measure drug clearance. Reduced creatinine generation, fluid shifts and rapidly changing filtration can make creatinine‐based estimates misleading, whereas genuinely augmented renal clearance can cause insufficient drug exposure. These processes can coexist.
Ming‐Shen Lin, Kuo‐Fan Liao
wiley +1 more source
Prenatal exposure to gabapentinoids and the risk of neurodevelopmental disorders
Gabapentin and pregabalin are used to treat focal seizures, but are mainly prescribed in practice for neuropathic pain, along with various off-label indications, including mental-health disorders. There has been a noticeable increase in the dispensing of
Laure Sillis, Krista Huybrechts
core +2 more sources
Incidence and Costs of Gabapentinoids-Associated Adverse Events
, 2023 Scoping Review Protocol Goal of the review Three gabapentinoids (gabapentin, pregabalin, and mirogabalin) are currently approved for medical use for conditions such as seizures, neuropathic pain, and anxiety disorders.
Tania Morin (14834869) +4 more
core +1 more source