Results 21 to 30 of about 4,888 (188)

Comparison of Oral Labetolol and Oral Pregabalin in Attenuating Pressor Response to Endotracheal Intubation in Patients undergoing Mastoidectomy under General Anaesthesia- A Randomised Control Study [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Direct laryngoscopy and tracheal intubation provoke stress response side-effects in the form of hypertension, tachycardia, and dysrhythmia which are long-standing concerns for anaesthetists. Various drugs and techniques have been tried over
Ambar Khan, Shirin Parveen, Danish Ahmad , Imran Mehdi, Saurabh Arya, Garima Chaurasia, Pankaj Malik, Mohammed Sameer Ahmad   +7 more
doaj   +1 more source

Heme oxygenase-1 inducer and carbon monoxide–releasing molecule enhance the effects of gabapentinoids by modulating glial activation during neuropathic pain in mice

PAIN Reports, 2018
. Introduction:. Neuropathic pain is one of the most difficult-to-treat symptoms. Although gabapentinoids are classified as first-line drugs, they have only modest efficacy. Objectives:. The aim of this study was to investigate whether treatment with the
Kohei Godai, Yuichi Kanmura
doaj   +1 more source

ON THE ADDICTIVE POWER OF GABAPENTINOIDS: A MINI-REVIEW [PDF]

Psychiatria Danubina, 2018
The gabapentinoids gabapentin and pregabalin have been related to addiction citing pharmacovigilance data, some case presentations and increasing reports mainly from methadone maintenance treatment programs or emergency medicine. Most of these reports were based on patients with another current or previous substance use disorder (SUD). According to the
Bonnet, Udo, Richter, Emily-Lisa, Isbruch, Katrin, Scherbaum, Norbert   +3 more
openaire   +3 more sources

Current Evidence on Abuse and Misuse of Gabapentinoids [PDF]

Drug Safety, 2020
This review summarizes current evidence on the abuse and misuse of the gabapentinoids pregabalin and gabapentin. Pharmacovigilance studies, register-based studies, surveys, clinical toxicology studies, and forensic toxicology studies were identified and scrutinized with the goal to define the problem, identify risk factors, and discuss possible methods
Staffan Hägg, Anna K. Jönsson, Johan Ahlner   +2 more
openaire   +3 more sources

Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth

Pain and Therapy, 2020
Introduction Recent years have seen a dramatic escalation of off-label prescribing for gabapentin and pregabalin (gabapentinoids) owing in part to generic versions of each being released over the past two decades, but also in part as a response to ...
Heath McAnally, Udo Bonnet, Alan D. Kaye
doaj   +1 more source

The effect of opioid analgesics, benzodiazepines, gabapentinoids, and opioid agonist treatment on mortality risk among opioid-dependent people.

International Journal of Population Data Science, 2022
Background As dispensings for benzodiazepines and gabapentinoids have increased in recent years, risk of increased mortality has been identified, particularly when used with opioids. There is limited research examining use of these medicines among people
Chrianna Bharat, Natasa Gisev, Sebastiano Barbieri, Tim Dobbins, Sarah Larney, Michael Farrell, Louisa Degenhardt   +6 more
doaj   +1 more source

Gabapentinoids: A review of the literature

, 2021
The objective of this review is to produce a synthesis of the state of knowledge regarding the epidemiology, pharmacology, clinical and analytical toxicology of gabapentinoids. The pharmacological class of gabapentinoids is mainly represented by gabapentin and pregabalin, which were marketed around the 2000s. Soon after their marketing, cases of misuse
Bargel, Sophie, Becam, Jenny, Chanu, Lucie, Lanot, Thomas, Martin, Marie, Vaucel, Jules, Willeman, Theo, Fabresse, Nicolas   +7 more
openaire   +1 more source

Long‐term prediction of epilepsy following traumatic brain injury among veterans using routine clinical data

Epilepsia, EarlyView.
Abstract Objective Despite elevated risk for epilepsy following traumatic brain injury (TBI), there are limited tools to assess epilepsy risk following TBI using routine clinical data. The objective of this study was to develop and validate a machine learning approach to predict the onset of posttraumatic epilepsy (PTE) over varying time horizons ...
Mustafa Ozmen, Shashank Vadlamani, James J. Gugger, Megan Amuan, Ramon Diaz‐Arrastia, Mary Jo Pugh, Eamonn Kennedy   +6 more
wiley   +1 more source

Diabetic painful polyneuropathy treatment [PDF]

Serbian Journal of Anesthesia and Intensive Therapy, 2017
Diabetic peripheral neuropathies (DPN) are a heterogeneous group of disorders caused by neuronal dysfunction in patients with diabetes. Among all acquired polyneuropathy, diabetic polyneuropathy is the most common, and therefore the most important one ...
Terzić Branka
doaj   +1 more source

Limb Compression Therapy and Chemotherapy‐Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self‐Controlled Study(NEURO‐GLOVE Trial)

International Journal of Cancer, EarlyView.
With no effective drug‐based prevention strategies available for chemotherapy‐induced peripheral neuropathy (CIPN), research in neuroprotective approaches has grown. Of particular interest is mechanical compression, which may protect nerves by temporarily reducing blood flow during treatment. The authors here conducted a prospective trial in women with
Kadriye Başkurt, Galip Can Uyar, Enes Yeşilbaş, Fatma Zehra Altunç, Damla Erimhan Çevik, İsmet Murat Melek, Yasemin Eren, Ömür Berna Çakmak Öksüzoğlu, Kadriye Bir Yücel, Antonio Di Meglio, Isabelle Ray‐Coquard, Osman Sütcüoğlu   +11 more
wiley   +1 more source