Results 21 to 30 of about 6,345 (201)

Prenatal exposure to gabapentinoids and the risk of neurodevelopmental disorders

Gabapentin and pregabalin are used to treat focal seizures, but are mainly prescribed in practice for neuropathic pain, along with various off-label indications, including mental-health disorders. There has been a noticeable increase in the dispensing of
Laure Sillis, Krista Huybrechts
core   +8 more sources

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid-Related Adverse Events Following Surgery for Breast Cancer. [PDF]

Clin Pharmacol Ther
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Lai JH, Avanceña ALV, Cata JP, Barner JC, Giordano SH, Park C, Zhao H, Evoy KE, Lin JK, Spencer JC, Chavez-MacGregor M, Hunt KK, Wanis KN.   +12 more
europepmc   +2 more sources

Effects of Opioids, Benzodiazepines, Gabapentinoids, and Antidepressants on Fracture Risk in Alcohol-Related Cirrhosis. [PDF]

Liver Int
Background: Patients with alcohol-related liver cirrhosis (ALD cirrhosis) have an increased risk of falls and fractures. Opioids, benzodiazepines, gabapentinoids, and antidepressants are known to increase fall risk.
Kraglund F, Deleuran T, Storgaard MA, Sædder E, Jepsen P.   +4 more
europepmc   +2 more sources

Gabapentinoids: a therapeutic review

Australian Prescriber, 2023
The Australian Therapeutic Goods Administration's approved indications for prescription of gabapentinoids are refractory focal epilepsy and neuropathic pain. Use of gabapentinoids outside of the approved indications is common, but evidence for this is limited, especially for chronic nonspecific back pain and nonradicular leg pain.
Akshay Athavale, Bridin Murnion
openaire   +2 more sources

Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Pharmacotherapy may reduce overall suicide risk in bipolar disorder, but prescribed medicines can also be causative agents in suicidal and accidental poisonings. This nationwide, nested case–control study utilized data from several national registers in Finland in 1996–2018.
Salmelainen J, Tiihonen M, Taipale H, Lieslehto J, Tanskanen A, Tiihonen J, Hamina A.   +6 more
europepmc   +2 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Efficacy of gabapentinoids for acute herpes zoster in preventing postherpetic neuralgia: a systematic review of randomized controlled trials [PDF]

, 2022
Gabapentinoids (e.g., gabapentin and pregabalin) have been established as a treatment for postherpetic neuralgia (PHN), but their effects on the prevention of PHN are unclear.
Halim, Paulus Anthony, Kurniawan, Kristian, Menaldi, Sri Linuwih   +2 more
core   +1 more source

Concurrent use of prescription gabapentinoids with opioids and risk for fall-related injury among older US Medicare beneficiaries with chronic noncancer pain: A population-based cohort study

PLoS Medicine, 2022
Background Gabapentinoids are increasingly prescribed to manage chronic noncancer pain (CNCP) in older adults. When used concurrently with opioids, gabapentinoids may potentiate central nervous system (CNS) depression and increase the risks for fall.
Cheng Chen, Almut G. Winterstein, Wei-Hsuan Lo-Ciganic, Patrick J. Tighe, Yu-Jung Jenny Wei   +4 more
doaj   +3 more sources

Gabapentinoid prescription in Oral Medicine and Oral Surgery practice. Part II − a systematic scoping review of the literature

Journal of Oral Medicine and Oral Surgery, 2020
Introduction: Gabapentinoids, pregabalin and gabapentin, neuronal voltage-gated calcium channel inhibitors are first-line treatments for painful neuropathic conditions (and several non-neuropathic painful conditions).
Sulukdjian Arek, L'Homme Richard, Chanlon Audrey, Moreau Nathan   +3 more
doaj   +1 more source

Ranking the Harm of Psychoactive Drugs Including Prescription Analgesics to Users and Others–A Perspective of German Addiction Medicine Experts

Frontiers in Psychiatry, 2020
Background: Over the past 15 years, comparative assessments of psychoactive substance harms to both users and others have been compiled by addiction experts.
Udo Bonnet, Udo Bonnet, Michael Specka, Michael Soyka, Thomas Alberti, Stefan Bender, Torsten Grigoleit, Leopold Hermle, Jörg Hilger, Thomas Hillemacher, Thomas Hillemacher, Thomas Kuhlmann, Jens Kuhn, Jens Kuhn, Christian Luckhaus, Christel Lüdecke, Jens Reimer, Jens Reimer, Udo Schneider, Welf Schroeder, Markus Stuppe, Gerhard A. Wiesbeck, Norbert Wodarz, Heath McAnally, Heath McAnally, Norbert Scherbaum   +25 more
doaj   +1 more source