Results 1 to 10 of about 4,807 (112)
Frontiers in Pharmacology, 2021 Background: There is growing concern over the increasing utilisation trends of opioids and gabapentinoids across but there is lack of data assessing and comparing the utilisation trends across the four United Kingdom countries.
Amanj Kurdi, Kurdi Amanj
exaly +3 more sources
Effectiveness of gabapentinoids in orthopedic surgeries: a systematic review and meta-analysis of postoperative pain, and opioid-sparing effects [PDF]
BMC AnesthesiologyBackground Gabapentinoids, including gabapentin and pregabalin, are increasingly used in perioperative settings to manage postoperative pain. Despite their widespread use, the clinical evidence regarding the treatment of gabapentinoids in terms of ...
Fatimah Abdulaziz Almuqad +6 more
doaj +2 more sources
Effectiveness of Gabapentinoids in Neuropathic Pain: A Single-Center Retrospective Study at a Specialized Institution in Mexico [PDF]
PharmacyBackground/Objectives: Gabapentinoids are first-line treatments for neuropathic pain (NP); however, real-world evidence regarding their safety and effectiveness in complex clinical populations remains limited.
Carlos Eduardo Estrada-De La Rosa +7 more
doaj +2 more sources
The impact of pregabalin and gabapentin on essential tremor: a systematic review and meta-analysis [PDF]
Clinical Parkinsonism & Related DisordersIntroduction: Essential tremor (ET) is a common neurological disorder characterized by involuntary rhythmic oscillations. Emerging evidence suggests that gabapentinoids, including gabapentin and pregabalin, may be effective in managing ET.
Hooman Pourbala +8 more
doaj +2 more sources
PLoS ONE, 2022 Background and objectiveGabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium.
Abida Shaheen +6 more
doaj +2 more sources
Characterization of hospitalized patients who received naloxone while receiving opioids with or without gabapentinoids [PDF]
Mental Health Clinician, 2021 Introduction: Gabapentin and pregabalin (gabapentinoids) can be given with opioids for opioid-sparing and adjuvant analgesic effects. In the context of certain comorbidities and high dosages, coadministration of these agents can lead to respiratory ...
Payal H. Desai, PharmD, BCCCP +4 more
doaj +1 more source
Opioid and gabapentinoid prescriptions in England from 2015 to 2020
PLoS ONE, 2022 Purpose Concerns gradually arose about misuse of gabapentinoids (gabapentin and pregabalin), especially when used in combination with opioids. Because it can be a driver of usage, trends in prescribing habits may be interesting to analyse.
Yixue Xia, Patrice Forget
doaj +2 more sources
PLoS Medicine, 2022 Background Gabapentinoids are increasingly prescribed to manage chronic noncancer pain (CNCP) in older adults. When used concurrently with opioids, gabapentinoids may potentiate central nervous system (CNS) depression and increase the risks for fall.
Cheng Chen +4 more
doaj +3 more sources
Frontiers in Pharmacology, 2023 Background and Objective: Multimodal management of spinal stenosis is on the rise, and central sensitisation inhibitors are playing an essential role in the treatment of central sensitisation processes.
Telmo Martínez +3 more
doaj +1 more source
Novel Drug Targets and Emerging Pharmacotherapies in Neuropathic Pain
Pharmaceutics, 2023 Neuropathic pain is a debilitating condition characterized by abnormal signaling within the nervous system, resulting in persistent and often intense sensations of pain.
Jurga Bernatoniene +3 more
doaj +1 more source