Results 11 to 20 of about 6,786 (213)

Characterization of hospitalized patients who received naloxone while receiving opioids with or without gabapentinoids [PDF]

Mental Health Clinician, 2021
Introduction: Gabapentin and pregabalin (gabapentinoids) can be given with opioids for opioid-sparing and adjuvant analgesic effects. In the context of certain comorbidities and high dosages, coadministration of these agents can lead to respiratory ...
Payal H. Desai, PharmD, BCCCP, Olesya Taylor, PharmD, BCPS, Kunal J. Shah, PharmD, Kirk E. Evoy, PharmD, BCACP, BC-ADM, CTTS, Alyssa M. Peckham, PharmD, BCPP   +4 more
doaj   +3 more sources

ON THE ADDICTIVE POWER OF GABAPENTINOIDS: A MINI-REVIEW [PDF]

Psychiatria Danubina, 2018
The gabapentinoids gabapentin and pregabalin have been related to addiction citing pharmacovigilance data, some case presentations and increasing reports mainly from methadone maintenance treatment programs or emergency medicine. Most of these reports were based on patients with another current or previous substance use disorder (SUD). According to the
Bonnet, Udo, Richter, Emily-Lisa, Isbruch, Katrin, Scherbaum, Norbert   +3 more
openaire   +5 more sources

Gabapentinoids for the treatment of stroke

Neural Regeneration Research, 2023
Gabapentinoid drugs (pregabalin and gabapentin) have been successfully used in the treatment of neuropathic pain and in focal seizure prevention. Recent research has demonstrated their potent activities in modulating neurotransmitter release in neuronal ...
Ying Zhang, Chenyu Zhang, Xiaoli Yi, Qi Wang, Tiejun Zhang, Yuwen Li   +5 more
doaj   +3 more sources

Current Evidence on Abuse and Misuse of Gabapentinoids [PDF]

Drug Safety, 2020
This review summarizes current evidence on the abuse and misuse of the gabapentinoids pregabalin and gabapentin. Pharmacovigilance studies, register-based studies, surveys, clinical toxicology studies, and forensic toxicology studies were identified and scrutinized with the goal to define the problem, identify risk factors, and discuss possible methods
Staffan Hägg, Anna K. Jönsson, Johan Ahlner   +2 more
openaire   +4 more sources

Effectiveness of gabapentinoids in orthopedic surgeries: a systematic review and meta-analysis of postoperative pain, and opioid-sparing effects

BMC Anesthesiology
Background Gabapentinoids, including gabapentin and pregabalin, are increasingly used in perioperative settings to manage postoperative pain. Despite their widespread use, the clinical evidence regarding the treatment of gabapentinoids in terms of ...
Fatimah Abdulaziz Almuqad, Ahmed Adel Almuhammady, Ghaida Talea Alsaedi, Joud Adel Osailan, Sulafah Ibrahim Alalawi, Yousef Abdullah Rahmah Allah, Ahmed Osailan   +6 more
doaj   +2 more sources

Opioid and gabapentinoid prescriptions in England from 2015 to 2020.

PLoS ONE, 2022
PurposeConcerns gradually arose about misuse of gabapentinoids (gabapentin and pregabalin), especially when used in combination with opioids. Because it can be a driver of usage, trends in prescribing habits may be interesting to analyse. The aim of this
Yixue Xia, Patrice Forget
doaj   +2 more sources

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid-Related Adverse Events Following Surgery for Breast Cancer. [PDF]

Clin Pharmacol Ther
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Lai JH, Avanceña ALV, Cata JP, Barner JC, Giordano SH, Park C, Zhao H, Evoy KE, Lin JK, Spencer JC, Chavez-MacGregor M, Hunt KK, Wanis KN.   +12 more
europepmc   +2 more sources

Gabapentinoids: a therapeutic review

Australian Prescriber, 2023
The Australian Therapeutic Goods Administration's approved indications for prescription of gabapentinoids are refractory focal epilepsy and neuropathic pain. Use of gabapentinoids outside of the approved indications is common, but evidence for this is limited, especially for chronic nonspecific back pain and nonradicular leg pain.
Akshay Athavale, Bridin Murnion
openaire   +2 more sources

Efficacy and safety of pregabalin and gabapentin in spinal stenosis: a systematic review and meta-analysis

Frontiers in Pharmacology, 2023
Background and Objective: Multimodal management of spinal stenosis is on the rise, and central sensitisation inhibitors are playing an essential role in the treatment of central sensitisation processes.
Telmo Martínez, Gonzalo Mariscal, Jose Enrique de la Rubia Ortí, Carlos Barrios   +3 more
doaj   +1 more source

Novel Drug Targets and Emerging Pharmacotherapies in Neuropathic Pain

Pharmaceutics, 2023
Neuropathic pain is a debilitating condition characterized by abnormal signaling within the nervous system, resulting in persistent and often intense sensations of pain.
Jurga Bernatoniene, Arunas Sciupokas, Dalia Marija Kopustinskiene, Kestutis Petrikonis   +3 more
doaj   +1 more source