Results 61 to 70 of about 6,786 (213)
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Risk‐reducing salpingo‐oophorectomy (RRSO) is the cornerstone of ovarian cancer prevention for women with hereditary cancer predisposition syndromes. When performed before natural menopause, however, RRSO induces immediate surgical menopause, with vasomotor symptoms, sexual dysfunction, accelerated bone loss, and potential long‐term ...
Agnaldo Lopes da Silva Filho +7 more
wiley +1 more source
Trends in pregabalin misuse and abuse: A 25-year bibliometric perspective [PDF]
Journal of Medical BiochemistryBackground: Originally classified among antiepileptic drugs, pregabalin has been prescribed for clinical conditions such as neuropathic pain, generalised anxiety disorder, and fibromyalgia.
Aksun Saliha +3 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota +14 more
wiley +1 more source
The impact of pregabalin and gabapentin on essential tremor: a systematic review and meta-analysis
Clinical Parkinsonism & Related DisordersIntroduction: Essential tremor (ET) is a common neurological disorder characterized by involuntary rhythmic oscillations. Emerging evidence suggests that gabapentinoids, including gabapentin and pregabalin, may be effective in managing ET.
Hooman Pourbala +8 more
doaj +1 more source
Addiction, EarlyView.Abstract Aims To determine: (1) Population rates of fatal methylenedioxymethamphetamine (MDMA)‐related poisoning over the period 2016–2023, years with high closure rates in the National Coronial Information System (NDIS); (2) the case characteristics of known cases of fatal MDMA‐related poisoning, 2016–2025; and (3) whether there have been changes in ...
Shane Darke +5 more
wiley +1 more source
Anaesthesia, EarlyView.Summary Introduction The Procedure Specific Postoperative Pain Management (PROSPECT) collaboration develops evidence‐based recommendations integrating analgesic efficacy, safety and functional recovery. Since publication of the 2021 PROSPECT guidelines for total hip arthroplasty, new evidence, particularly on motor‐sparing regional techniques, has ...
Michele Carella +8 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Gabapentinoids and Risk of Hip Fracture
JAMA Network OpenImportance The increased use of gabapentinoids has been most pronounced in older people who are also susceptible to hip fractures. Objective To investigate the overall association between gabapentinoids and the risk of hip fractures ...
Leung, Miriam T. Y. +6 more
openaire +2 more sources
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Impact of Semaglutide Introduction on the Use of Concomitant Medications: An Interrupted Time Series
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims To evaluate the impact of semaglutide initiation for weight management on the use of concomitant medications commonly prescribed for obesity‐related comorbidities. Materials and Methods We conducted a nationwide interrupted time series study using data from Danish registers, including adults initiating semaglutide for weight management ...
Noémie Roland +8 more
wiley +1 more source