Results 71 to 80 of about 4,888 (188)

Deprescription of Psychotropics in Children and Adolescents: Systematic Review of Guidelines and Development of a Deprescribing Algorithm

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Background Psychotropics are increasingly prescribed in paediatrics despite limited evidence regarding their benefits and effectiveness. Although deprescribing approaches are established in adults, structured paediatric strategies remain poorly defined.
Paul‐Benoît Fargier, Mark Horowitz, Rodolphe Charles, Valérie Rousselon, Erik Fakra, Marie‐Noëlle Beyens, Marie‐Laure Laroche   +6 more
wiley   +1 more source

Gabapentinoids-Related Delirium Adverse Events: A Real-World Study from 2004 to 2022 Based on FAERS

Journal of Pain Research
Zhongbiao Nie,1 Cuilv Liang,2 Zhihong Li,1 Xinqiang Han,3 Ran Zhang4 1Department of Pharmacy, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, People’s ...
Nie Z, Liang C, Li Z, Han X, Zhang R
doaj  

A highly aqueous HPLC-PDA method for the assay of gabapentin and pregabalin: applications in pharmaceutical analysis, dissolution testing, and forensic screening

Frontiers in Chemistry
IntroductionGabapentinoids, particularly pregabalin (PGL) and gabapentin (GBP), are widely used for neurological and psychiatric conditions but are increasingly linked to misuse and forensic challenges.
Fatimah M. Alamri, Fatimah M. Alamri, Taher Sahlabji, Yahya M. Alshehri, Ibrahim A. Al Othaim, Fahad S. Aldawasri, Abubakr M. Idris   +6 more
doaj   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study

International Journal of General Medicine, 2023
Marko Antunovic,1,2 Slavica Vucinic,1,2 Jelena Kotur-Stevuljevic,3 Kristijan Krstic,4 Jasmina Jovic-Stosic,1,2 Vesna Kilibarda,1,2 Natasa Perkovic-Vukcevic,1,2 Snezana Djordjevic1,2 1Medical Faculty Military Medical Academy, University of Defense ...
Antunovic M, Vucinic S, Kotur-Stevuljevic J, Krstic K, Jovic-Stosic J, Kilibarda V, Perkovic-Vukcevic N, Djordjevic S   +7 more
doaj  

Gabapentinoids In Pain Setting

Journal of Pain & Relief, 2013
Surgical incision induces central and peripheral sensitization and hyperalgesia, and if remain untreated may lead to chronic postoperative pain after surgery. Antihyperalgesic drugs improve postoperative pain by preventing the development of central sensitization [1].
openaire   +1 more source

Post‐ICU Psychotropic Medication Initiation in Nonagenarian Sepsis Survivors

Journal of the American Geriatrics Society, EarlyView.
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki   +2 more
wiley   +1 more source

The Opioid Safety Toolkit: An interactive prescription opioid safety toolkit to increase opioid safety literacy and behaviours among people prescribed opioids for pain—a randomised controlled trial

Addiction, Volume 121, Issue 8, Page 2071-2082, August 2026.
Abstract Background and aims Prescription opioid‐related harm remains a significant public health concern. This study aimed to evaluate the efficacy of the Opioid Safety Toolkit, a co‐designed, interactive online resource, in increasing naloxone uptake and healthcare provider discussions among adults prescribed opioids for pain.
Suzanne Nielsen, Frederick Fox, Tina Lam, Alex Waddell, Monica Jung, Bosco Rowland, Jessica Watterson, Dhruv Basur, Chris Prawira, Joshua Paolo Seguin, Patrick Olivier, Jarrod McMaugh, Paul Dietze, Louisa Picco   +13 more
wiley   +1 more source

Temporal Drivers of Opioid‐Related ED Visits: An Ensemble Machine Learning Study With Consensus‐Based Feature Attribution

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Identification of modifiable risk factors for prescription opioid use disorder (OUD)‐related emergency department (ED) visits (ICD‐10 F11.xx) is a clinical priority; however, most published models remain cross‐sectional and lack pharmacogenomic (PGx) enrichment or dual‐method feature confirmation. Using Virginia All‐Payer Claims Database (APCD)
R. Jerome Dixon, Elvin T. Price
wiley   +1 more source

Prescribing Patterns of Gabapentinoids in Patients with Chronic Obstructive Pulmonary Disorder

COPD
In 2019, the U.S. Food and Drug Administration (FDA) issued a warning regarding the risk of serious respiratory depression in patients using gabapentin or pregabalin who have respiratory risk factors, including those with chronic obstructive pulmonary ...
Mollie Vergara, Mate Michael Soric, Olivia King, Reece Bullock, Brandon Skory, Kelly Bole, Anika Englehart, Nita Mara, Amgad Moqbl, Manysha Patel, Alexandra Dimit   +10 more
doaj   +1 more source