Results 71 to 80 of about 6,345 (201)

Perioperative Gabapentinoids [PDF]

Anesthesiology, 2020
Evan D, Kharasch, J David, Clark, Sachin, Kheterpal   +2 more
openaire   +2 more sources

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Gabapentinoids and Risk of Hip Fracture

JAMA Network Open
ImportanceThe increased use of gabapentinoids has been most pronounced in older people who are also susceptible to hip fractures.ObjectiveTo investigate the overall association between gabapentinoids and the risk of hip fractures and the stratified association across age groups, frailty status, and history of chronic kidney disease.Design, Setting, and
Leung, Miriam T. Y., Turner, Justin P., Marquina, Clara, Ilomäki, Jenni, Tran, Tim, Bykov, Katsiaryna, Bell, J. Simon   +6 more
openaire   +2 more sources

Gabapentinoids for Chronic Pain: A Comprehensive Review of Current Literature on Efficacy, Safety and Withdrawal

, 2021
Gabapentinoids, pregabalin (LyricaTM) and gabapentin (NeurontinTM) are anticonvulsants that have been approved for chronic pain conditions such as diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, and are also widely prescribed off ...
Amy Kathryn Granger
core   +1 more source

Gabapentinoid prescriptions for neuropathic and musculoskeletal pain in Lebanon

Future Science OA
Aim: The purpose of this study is to analyze the different characteristics of gabapentinoids prescription by Lebanese orthopedics surgeons. Methods: This is an observational, cross-sectional study using a survey which was carried out in collaboration ...
Joe Rassi, Stephanie Khazaka, Sani Hlais, Stephanie Rassi, Mohammad Daher, Toufic Samaha   +5 more
doaj   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

Characterizing Gabapentinoid Use Among Patients With Isolated Low Back Pain

Global Spine Journal
Study Design Retrospective cohort study. Objectives Gabapentinoids have been increasingly studied as a non-narcotic option for neuropathic and postoperative pain.
Gwyneth C. Maloy BA, Scott J. Halperin BS, Philip P. Ratnasamy BS, Jonathan N. Grauer MD   +3 more
doaj   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma

Immunology &Cell Biology, EarlyView.
(Left)The identification and elimination of tumour cells is enabled by the infiltration of functional innate and adaptive immune effectors into the TME, such as natural killer cells (NK cells) and cytotoxic T cells (CD8 T cells). Effective innate and adaptive immune responses facilitate immunological control of malignant outgrowth.
Sarah J. MacDonald, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Terence J. O'Brien, Rosalind L. Jeffree, Mastura Monif   +6 more
wiley   +1 more source

iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau

European Journal of Cell Biology
Frontotemporal Lobar Degeneration (FTLD) is a neurodegenerative disorder that affects the frontal and temporal lobes, which are crucial for regulating personality, behavior, and language.
Keiko Imamura, Ayako Nagahashi, Aya Okusa, Tomoki Sakasai, Kayoko Tsukita, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Naruhiko Sahara, Nicholas M. Kanaan, Makoto Higuchi, Kohji Mori, Manabu Ikeda, Haruhisa Inoue   +13 more
doaj   +1 more source