Results 1 to 10 of about 633 (112)

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

Biomedicines, 2023
Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal
Tami Igarashi, Hiroki Yanagi, Masayuki Yagi, Masamitsu Ichihashi, Genji Imokawa   +4 more
doaj   +1 more source

Decrease in Myelin-Associated Lipids Precedes Neuronal Loss and Glial Activation in the CNS of the Sandhoff Mouse as Determined by Metabolomics

Metabolites, 2020
Sandhoff disease (SD) is a lysosomal disease caused by mutations in the gene coding for the β subunit of β-hexosaminidase, leading to deficiency in the enzymes β-hexosaminidase (HEX) A and B.
Emmanuelle Lecommandeur, Maria Begoña Cachón-González, Susannah Boddie, Ben D. McNally, Andrew W. Nicholls, Timothy M. Cox, Julian L. Griffin   +6 more
doaj   +1 more source

Glycosphingolipids in Filamentous Fungi: Biological Roles and Potential Applications in Cosmetics and Health Foods

Frontiers in Microbiology, 2021
Filamentous fungi are a group of economically important fungi used in the production of fermented foods, industrial enzymes, and secondary metabolites. Glycosphingolipids (GSLs) as constituents of lipid rafts are involved in growth, differentiation, and ...
Chunmiao Jiang, Jinxin Ge, Bin He, Bin Zeng, Bin Zeng   +4 more
doaj   +1 more source

CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism

Journal of Lipid Research, 2021
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT.
Christopher D. Green, Cynthia Weigel, Clement Oyeniran, Briana N. James, Deanna Davis, Usha Mahawar, Jason Newton, Binks W. Wattenberg, Michael Maceyka, Sarah Spiegel   +9 more
doaj   +1 more source

Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]

, 2017
Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong, Hung, Jung-Tung, Yu, Alice L   +2 more
core   +4 more sources

High-Density Lipoprotein Lipidomics and Mortality in CKD

Kidney Medicine, 2023
Rationale & Objective: Patients with chronic kidney disease (CKD) have dysfunctional high-density lipoprotein (HDL) particles that lack cardioprotective properties; altered lipid composition may be associated with these changes.
Benjamin Lidgard, Andrew N. Hoofnagle, Leila R. Zelnick, Ian H. de Boer, Amanda M. Fretts, Bryan R. Kestenbaum, Rozenn N. Lemaitre, Cassianne Robinson-Cohen, Nisha Bansal   +8 more
doaj   +1 more source

Vitamin K enhances the production of brain sulfatides during remyelination. [PDF]

PLoS ONE, 2018
Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system.
Daniela C Popescu, He Huang, Naveen K Singhal, Leah Shriver, Jennifer McDonough, Robert J Clements, Ernest J Freeman   +6 more
doaj   +1 more source

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]

, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines.
Decruy, Tine, Elewaut, Dirk, Froeyen, Mathy, Guillaume, Joren, Janssens, Jonas, Remesh, Soumya G, Risseeuw, Martijn, Van Calenbergh, Serge, Wang, Jing, Zajonc, Dirk M   +9 more
core   +1 more source

Quantitative analysis of brain galactosylceramides by high performance liquid chromatography of their perbenzoyl derivatives

Journal of Lipid Research, 1976
A high performance liquid chromatographic (HPLC) method for analysis of galactosylceramides as their benzoyl derivatives has been devised. Samples containing 10-150 nmoles of monohexosylceramides are benzoylated by heating for 60 min at 60 ° C in 0.5 ml ...
E H McCluer, J E Evans
doaj   +1 more source

Identification of a xylose-containing cerebroside in the salt gland of the herring gull

Journal of Lipid Research, 1972
A pentose-containing cerebroside has been identified in the salt gland of the herring gull, using mass spectrometry of acetyl and trimethylsilyl derivatives.
Karl-Anders Karlsson, Bo E. Samuelsson, Göran O. Steen   +2 more
doaj   +1 more source