Results 11 to 20 of about 633 (112)

Cholesterol's interfacial interactions with galactosylceramides [PDF]

Biochemistry, 1994
Recently, the influence of acyl structure on galactosylceramide's (GalCer) interfacial phase behavior was studied [Ali, S., Smaby, J. M., & Brown, R.E. (1993) Biochemistry 32, 11696-11703]. Here, we show that acyl structure is a key parameter controlling GalCer's ability to interact with cholesterol.
S, Ali, J M, Smaby, H L, Brockman, R E, Brown   +3 more
openaire   +2 more sources

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota [PDF]

, 2013
While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified.
Bluestone, Jeffrey A., Clardy, Jon, Comstock, Laurie E., Fischbach, Michael A., Kashyap, Purna C., Kronenberg, Mitchell, Penaranda, Cristina, Sonnenburg, Justin L., Wieland Brown, Laura C., Williams, Brianna B.   +9 more
core   +4 more sources

Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi

Marine Drugs, 2013
The marine sponge, Axinyssa djiferi, collected on mangrove tree roots in Senegal, was investigated for glycolipids. A mixture containing new glycosphingolipids, named axidjiferoside-A, -B and -C, accounted for 0.07% of sponge biomass (dry weight) and for
Gilles Barnathan, Gaëtane Wielgosz-Collin, Emilie Genin-Seward, Jean-Michel Kornprobst, Philippe M. Loiseau, Philippe Grellier, Monique Clément, Christos Roussakis, Fereshteh Farokhi   +8 more
doaj   +1 more source

Implications of lymphocyte anergy to glycolipids in multiple sclerosis (MS): iNKT cells may mediate the MS infectious trigger [PDF]

, 2013
Immunogenic lipids may play key roles in host defenses against infection and in generating autoimmune inflammation and organ-specific damage. In multiple sclerosis (MS) there are unequivocal autoimmune features and vulnerability to aggravation or ...
Hogan, Edward L., O’Keeffe, Joan, Podbielska, Maria   +2 more
core   +3 more sources

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]

, 2020
CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun, Cloots, Eva, De Geest, Bruno, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Gysens, Fien, Janssens, Sophie, Maelegheer, Margaux, Moody, D Branch, Venken, Koen, Verheugen, Eveline   +12 more
core   +2 more sources

Sulfatide inhibits  -galactosylceramide presentation by dendritic cells [PDF]

International Immunology, 2012
Sulfatide-reactive type II NKT cells, the so-called non-invariant NKT (non-iNKT) cells, have been shown to counteract invariant NKT (iNKT) cell activity. However, the effects of sulfatide on activation of iNKT cells by α-galactocylceramide (αGC) in the context of CD1d have not been studied in detail.
Mitsuhiro, Kanamori, Yusuke, Tasumi, Tomonori, Iyoda, Maki, Ushida, Kayo, Inaba   +4 more
openaire   +2 more sources

C-galactosylceramide: Synthesis and immunology [PDF]

Comptes Rendus. Chimie, 2011
A synthetic C-glycoside, α-C-galactosylceramide, is an active immunostimulant in mice. It displays better activity than α-O-galactosylceramide in several disease models. Syntheses of several α-C-galactosylceramides are described. Experiments that probe its immunostimulant activity are outlined.
openaire   +2 more sources

Aglycon diversity of brain sterylglucosides: structure determination of cholesteryl- and sitosterylglucoside[S]

Journal of Lipid Research, 2016
To date, sterylglucosides have been reported to be present in various fungi, plants, and animals. In bacteria, such as Helicobacter pylori, proton NMR spectral analysis of isolated 1-O-cholesteryl-β-d-glucopyranoside (GlcChol) demonstrated the presence ...
Hisako Akiyama, Kazuki Nakajima, Yoshiyuki Itoh, Tomoko Sayano, Yoko Ohashi, Yoshiki Yamaguchi, Peter Greimel, Yoshio Hirabayashi   +7 more
doaj   +1 more source

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]

, 2009
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Altschuler Y., Gabius H.J., Gendler S., Gouyer V., Hennebicq-Reig S., Huang J., Ligtenberg M.J., Ninomiya H., Yamashita K.   +8 more
core   +3 more sources

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1

FASEB BioAdvances, 2019
Very‐long‐chain fatty acids, with a chain length of >C20, are abundant in myelin sphingolipids. Recently, a de novo mutation in the ELOVL1 gene, which encodes fatty acid elongase, was identified in patients with neurocutaneous disorders involving skin ...
Masashi Isokawa, Takayuki Sassa, Satoko Hattori, Tsuyoshi Miyakawa, Akio Kihara   +4 more
doaj   +1 more source