Results 21 to 30 of about 633 (112)

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers[S]

Journal of Lipid Research, 2009
Sphingolipids are a highly diverse category of bioactive compounds. This article describes methods that have been validated for the extraction, liquid chromatographic (LC) separation, identification and quantitation of sphingolipids by electrospray ...
Rebecca L. Shaner, Jeremy C. Allegood, Hyejung Park, Elaine Wang, Samuel Kelly, Christopher A. Haynes, M. Cameron Sullards, Alfred H. Merrill, Jr.   +7 more
doaj   +1 more source

NKT Cells Stimulated by Long Fatty Acyl Chain Sulfatides Significantly Reduces the Incidence of Type 1 Diabetes in Nonobese Diabetic Mice [PDF]

, 2012
Sulfatide-reactive type II NKT cells have been shown to regulate autoimmunity and anti-tumor immunity. Although, two major isoforms of sulfatide, C16:0 and C24:0, are enriched in the pancreas, their relative role in autoimmune diabetes is not known. Here,
Aguilera, Carlos, Blumenfeld, Hartley, Buschard, Karsten, Delovitch, Terry L., Kumar, Vipin, Ly, Dalam, Mansson, Jan-Eric, Maricic, Igor, Subramanian, Lakshmimathy, Tohn, Robert   +9 more
core   +3 more sources

Prophylaxis of lipopolysaccharide-induced shock by α-galactosylceramide [PDF]

Journal of Leukocyte Biology, 2008
AbstractThe NKT cell ligand α-galactosylceramide and its synthetic homologue KRN7000 stimulate rapid and copious secretion of IFN-γ and TNF-α release, both of which are key mediators of LPS-induced shock. We showed that KRN7000, injected before or within 2 h after LPS challenge, was able to prevent endotoxic shock.
Guido, Sireci, Marco Pio, La Manna, Diana, Di Liberto, Marco, Lo Dico, Masaru, Taniguchi, Francesco, Dieli, Alfredo, Salerno   +6 more
openaire   +2 more sources

Structural Analysis of Fungal Cerebrosides

Frontiers in Microbiology, 2011
Of the ceramide monohexosides (CMHs), gluco- and galactosylceramides are the main neutral glycosphingolipids expressed in fungal cells. Their structural determination is greatly dependent on the use of mass spectrometric techniques, including fast atom ...
Eliana eBarreto-Bergter, Guilherme Lanzi Sassaki, Lauro eSouza   +2 more
doaj   +1 more source

Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists [PDF]

, 2015
Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro ...
ASPESLAGH, SANDRINE, Elewaut, Dirk, Guillaume, Joren, Pauwels, Nora, Van Calenbergh, Serge, Zajonc, Dirk   +5 more
core   +1 more source

Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice [PDF]

, 2018
Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models.
Cózar Bernal, María José, González Rodríguez, María Luisa, Motilva Sánchez, Virginia, Rabasco Álvarez, Antonio María, Rodríguez Luna, Azahara María, Talero Barrientos, Elena Mª, Ávila Román, Francisco Javier   +6 more
core   +1 more source

DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid[S]

Journal of Lipid Research, 2019
Cerebrosides, including glucosylceramides (GlcCers) and galactosylceramides (GalCers), are important membrane components of animal cells with deficiencies resulting in devastating lysosomal storage disorders. Their quantification is essential for disease
Hongbin Xu, Frederic R. Boucher, Thao T. Nguyen, Graeme P. Taylor, Julianna J. Tomlinson, Roberto A. Ortega, Brigitte Simons, Michael G. Schlossmacher, Rachel Saunders-Pullman, Walt Shaw, Steffany A.L. Bennett   +10 more
doaj   +1 more source

Immunoregulatory role of Jα281 T cells in aged mice developing lupus-like nephritis. [PDF]

, 2007
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these ...
Araki, Bendelac, Bennett, Chan, Cui, Fan, Filaci, Forestier, Gumperz, Hammond, Hong, Inui, Karadimitris, Kojo, Li, Martin, Matsuda, Mattner, Mendiratta, Mieza, Morita, Oishi, Peng, Peralbo, Porcelli, Richard, Satoh, Shivakumar, Singh, Singh, Singh, Singh, Stanic, Tsukahara, van der Vliet, Wallace, Wang, Wither, Yang, Yang, Zeng, Zeng   +41 more
core   +1 more source

Preclinical studies in Krabbe disease: A model for the investigation of novel combination therapies for lysosomal storage diseases [PDF]

, 2023
Krabbe disease (KD) is a lysosomal storage disease (LSD) caused by mutations in the galc gene. There are over 50 monogenetic LSDs, which largely impede the normal development of children and often lead to premature death.
Bongarzone, Ernesto R, Bradbury, Allison M, Heller, Gregory, Sands, Mark S   +3 more
core   +3 more sources

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism [PDF]

, 2017
Ovarian cancer is a very severe type of disease with poor prognosis. Treatment of ovarian cancer is challenging because of the lack of tests for early detection and effective therapeutic targets.
Braicu, Elena Ioana, Budczies, Jan, Darb-Esfahani, Silvia, Denkert, Carsten, Dietel, Manfred, Frezza, Christian, Heiskanen, Laura, Hilvo, Mika, Koistinen, Kaisa M., Kuhberg, Marc, Pöhö, Päivi, Schmitt, Wolfgang D., Sehouli, Jalid   +12 more
core   +3 more sources